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<h1 class="pagehead">Pipeline</h1>
<p class="introtext">Molecular Insight is focused on the critical unmet diagnostic and therapeutic needs of the prostate cancer patient. We are targeting the development of a proprietary small-molecule chemistry platform to improve detection of primary and metastatic prostate cancer and to provide a novel systemic radiotherapy for relapsed and metastatic prostate cancer.</p>
<table width="100%" border="0" cellspacing="2" cellpadding="0" class="tablepipeline">
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<th width="27%" scope="col">Product Candidate</th>
<th width="35%" scope="col">Indication</th>
<th width="38%" scope="col">Status</th>
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<td colspan="3" class="sectionhead"><strong>Diagnostic</strong></td>
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<td><a href="diagnostic.html"><sup>99m</sup>Tc-MIP-1404</a></td>
<td><p>Rapid, sensitive detection, staging and monitoring of primary and metastatic prostate cancer in soft tissue and bone by targeting prostate specific membrane antigen (PSMA)</p></td>
<td><p>Completed Phase 1 proof of concept and radiation dosimetry clinical trials in prostate cancer patients and healthy volunteers</p>
<p>Investigational New Drug application (IND) allowed in Q2 2012. Multi-center international Phase 2 clinical trial in high risk prostate cancer patients undergoing prostatectomy began in Q3 2012</p></td>
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<td colspan="3" class="sectionhead"><strong>THERAPEUTIC</strong></td>
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<td><a href="therapeutic.html"><sup>131</sup>I-MIP-1095</a></td>
<td>Systemic radiotherapy for metastatic prostate cancer by targeting PSMA with <sup>131</sup>I labeled small molecules</td>
<td><p>Demonstrated preclinical efficacy in rodent models of human prostate cancer</p>
<p>IND submission targeted for Q4 2012</p>
<p>Phase 1 dose escalation clinical trial planned to initiate in 2013</p></td>
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<td colspan="3" class="sectionhead"><strong>Discovery</strong></td>
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<td><a href="discovery.html">MIP-1500</a></td>
<td>Second generation systemic radiotherapy for prostate cancer enabling alternative beta and alpha emitting radionuclides to enhance tumor control and ease of use</td>
<td><p>Identified several classes of high affinity lead PSMA inhibitors</p>
<p>Ongoing optimization of pharma-cokinetics</p></td>
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<td><a href="discovery.html">MIP-2100</a></td>
<td>Radiation sensitizers for use in combination with <sup>131</sup>I-MIP-1095 to prolong duration, increase response, and enhance the efficacy of prostate cancer radiotherapy</td>
<td>Evaluation in preclinical models of human prostate cancer for synergy of several classes of molecular targeted chemotherapeutic agents in combination with radiotherapy</td>
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