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<h1>Women's Health</h1>
<p>The ABS team has extensive experience conducting various strategic and tactical, prospective and retrospective research and consulting services in women’s health. Examples of this work are presented here.</p>
<h2>Indications</h2>
<ul>
<li>Atrophic vaginitis</li>
<li>Breast cancer</li>
<li>Contraception</li>
<li>Dysfunctional uterine bleeding</li>
<li>Endometriosis</li>
<li>Fertility</li>
<li>Hormone replacement therapy (HRT)</li>
<li>Incontinence / overactive bladder (OAB)</li>
<li>In vitro fertilization</li>
<li>Menopause</li>
<li>Nuclear imaging</li>
<li>Osteoarthritis (OA)</li>
<li>Osteoporosis</li>
<li>Ovarian cancer</li>
<li>Pelvic prolapse</li>
<li>Preeclampsia</li>
<li>Pregnancy and peri-natal care</li>
<li>Rheumatoid arthritis (RA)</li>
</ul>
<h2>Strategic Consulting and Research Examples</h2>
<ul>
<li>Strategic outcomes research and reimbursement plan for a new technology for in vitro fertilization</li>
<li>Strategic environmental assessment of breast cancer, including biological, psychosocial, economic, and political issues</li>
<li>Strategic market intelligence information gathering for a fertility product</li>
<li>Strategic planning for pain therapy in RA and OA</li>
<li>Strategic assessment of breast cancer care</li>
<li>Systematic literature reviews of the burden of RA and OA</li>
<li>Systematic literature reviews of the clinical, economic, and health-related quality of life (HRQL) burden of endometriosis</li>
<li>Functional status instrument review for RA and OA</li>
<li>Systematic review in preeclampsia</li>
</ul>
<h2>Selected Prospective Studies</h2>
<ul>
<li>National Osteoporosis Risk Assessment™ (NORA™) longitudinal patient registry</li>
<li>Post-approval experience trial for OA</li>
<li>Urinary stress incontinence registry in North and South America, Europe, and the Middle East</li>
<li>Phase IV studies of HRT for menopause, an oral contraceptive, and a GnRH analog for endometriosis</li>
<li>HRQL assessment in ovarian cancer</li>
<li>Study of an MRI imaging system for the breast</li>
</ul>
<h2>Selected Retrospective Studies </h2>
<ul>
<li>Multiple longitudinal Medicare claims analyses of OAB and pelvic prolapse, including diagnostic/treatment patterns and clinical/economic outcomes</li>
<li>Medicare analysis of complications of OAB surgery</li>
<li>Medicare claims analysis of skeletal-related events in breast cancer</li>
<li>Analysis of NHANES III to determine the risk of osteoporosis by patient subgroups</li>
<li>Analysis of osteoporosis in Medicaid</li>
<li>Managed care analyses of atrophic vaginitis, endometriosis, and estrogen therapy</li>
<li>Study of breast cancer in Medicare</li>
</ul>
<h2>Selected Modeling Studies</h2>
<ul>
<li> Cost-effectiveness model of computer assisted breast cancer screening device using Monte-Carlo simulations</li>
<li>Cost-effectiveness models of HRT for short-term prevention of osteoporosis and for the management of menopausal symptoms</li>
<li>Cost-effectiveness of HRT, raloxifene and alendronate for osteoporotic fractures within a Medicaid population</li>
<li>Economic model in OAB</li>
<li>Markov model of the clinical/economic impact of agents in the prevention and treatment of osteoporosis in the U.S. and U.K.</li>
<li>Economic model of the value of double reading in mammography screening</li>
<li>Economic model in dysfunctional uterine bleeding</li>
</ul>
<h2>Selected Publications & Presentations of ABS Team Members</h2>
<p>Shulman LP, Portman DJ, Lee WC, Balu S, Joshi AV, Cobden D, Wang Q, Pashos CL. A retrospective managed care claims data analysis of medication adherence to vaginal estrogen therapy: Implications for clinical practice. J Women’s Health 2008; 17(4): 569-78. </p>
<p>Liu CL, Zaslavsky AM, Ganz ML, et al. The financial implications of availability and quality of a usual source of care for children with special health care needs. Matern Child Health J 2008; 12(2): 243-59.</p>
<p>Gerber MR, Wittenberg E, Ganz ML, et al. Intimate partner violence exposure and change in women’s physical symptoms over time. J Gen Intern Med 2008; 23(1): 64-9.</p>
<p>Anger JT, Litwin MS, Wang Q, Pashos CL, et al. The effect of age on outcomes after sling surgery for urinary incontinence. J Am Geriatr Soc 2007; 55(12): 1927-31.</p>
<p>McCloskey LA, Williams CM, Lichter E, Gerber M, Ganz ML, Sege R. Abused women disclose partner interference with health care: An unrecognized form of battering. J Gen Intern Med 2007; 22(8): 1067-72.</p>
<p>Anger JT, Litwin MS, Wang Q, Pashos CL, et al. Variations in stress incontinence and prolapse management by surgeon specialty. J Urol 2007; 178(4 Pt 1): 1411-7.</p>
<p>Anger JT, Rodriguez LV, Wang Q, Pashos CL, et al. The role of pre-operative testing on outcomes after sling surgery for stress urinary incontinence. J Urol 2007; 178(4): 1364-9.</p>
<p>Anger JT, Rodriguez LV, Wang Q, Chen E, Pashos CL, et al. Racial disparities in the surgical management of stress incontinence among female Medicare beneficiaries. J Urol 2007; 177(5): 1846-50.</p>
<p>Anger JT, Rodríguez LV, Wang Q, Pashos CL, et al. The role of provider volume on outcomes after sling surgery for stress urinary incontinence. J Urol 2007; 177(4): 1457-62.</p>
<p>Anger JT, Litwin MS, Wang Q, Pashos CL, et al. Complications of sling surgery among female Medicare beneficiaries. Obstet Gynecol 2007; 109(3): 707-14.</p>
<p>Gao X, et al. Health-related quality of life burden of women with endometriosis: a literature review. Curr Med Res Opin 2006; 22(9): 1787-97.</p>
<p>Gao X, Outley J, Botteman M, Spalding J, Simon JA, Pashos CL. The economic burden of endometriosis. Fertility & Sterility 2006; 86(6): 1561-72.</p>
<p>Wittenberg E, Lichter EL, Ganz ML, et al. Community preferences for health states associated with intimate partner violence. Medical Care 2006; 44: 738-44.</p>
<p>Kaestner R, Lee WC. The effect of welfare reform on prenatal care and birth weight. Health Economics 2005; 14(5): 497-511.</p>
<p>Mandelblatt JS, Schechter CB, Yabroff KR, et al. Benefits and costs of interventions to improve breast cancer outcomes in African American women. J Clin Oncol 2004; 22(13): 2554-66.</p>
<p>Stephens JM, Bell CF, Wong JM, Pena BM, Haider S, Pashos CL. Value of cyclooxygenase-2 specific inhibitors in the management of osteoarthritis. Expert Rev Pharmacoeconomics and Outcomes Research 2004; 4(4): 441-55.</p>
<p>Botteman MF, Shah NP, Lian J, Pashos CL, et al. A cost-effectiveness evaluation of two continuous-combined hormone therapies for the management of moderate-to-severe vasomotor symptoms. Menopause 2004; 11(3): 343-55.</p>
<p>Botteman MF, Wang Q, et al. Feasibility of simplifying complex decision trees via linear regression analysis: An application to cost effectiveness analysis of hormone therapy for menopausal symptoms. International Society for Pharmacoeconomics and Outcomes Research, 8th Annual Meeting, Arlington, VA, May 18-22, 2003.</p>
<p>Botteman MF, Shah N, Brandman J, Pashos CL. A cost-effectiveness evaluation of two continuous combined hormone replacement therapies for the management of menopausal symptoms and prevention of osteoporosis. North American Menopause Society, 13th Annual Meeting, Chicago, IL October 4-5, 2002.</p>
<p>Boone TB, Kusek JW, Nyberg LM, Steele G, Pashos CL, Grossman M, Diokno A, Bull S, Albrecht D. Treatment patterns and associated symptom improvement during six months of care for overactive bladder: a prospective, observational study. Clinical Therapeutics 2002; 24(3): 397-408.</p>
<p>Diokno A, Lee P, Zorn BH, Lenderking WR, Grossman MA, Bull SA, Albrecht D. Factors associated with clinical assessment of overactive bladder and selection of treatment. Clinical Therapeutics 2001; 23(9): 1542-51.</p>
<p>Seifeldin RA , Botteman MF, Tafesse E, Pashos CL, Taft LB, Elting LS. Chemotherapy-induced thrombocytopenia (CIT) attributable cost in patients with breast cancer, non-Hodgkin’s lymphoma or sarcoma. J Clin Oncol 2000; Vol.19; Abstract No.1715.</p>
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