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<h1>Urology</h1>
<p>The ABS team has extensive experience conducting various strategic and tactical, prospective and retrospective research and consulting services in urology. Examples of this work are presented here.</p>
<h2>Indications</h2>
<ul>
<li>Acute urinary retention</li>
<li>Benign prostatic hyperplasia</li>
<li>Bladder cancer</li>
<li>Overactive bladder / urinary incontinence</li>
<li>Prostate cancer</li>
<li>Sexual dysfunction</li>
</ul>
<h2>Strategic Consulting and Research Examples</h2>
<ul>
<li>Design of a health-related quality of life (HRQL) instrument for sexual dysfunction</li>
<li>Strategic input into positioning and pricing of an alpha-blocker in benign prostatic hyperplasia</li>
<li>Systematic literature reviews of patient and partner HRQL in sexual health</li>
<li>Systematic literature reviews of the clinical, economic and HRQL burden of bladder cancer</li>
<li>Literature synthesis of the epidemiology, diagnosis, and management of bladder cancer</li>
<li>Systematic review of electronic patient reported outcomes (PRO) instruments in prostate cancer</li>
</ul>
<h2>Selected Prospective Studies</h2>
<ul>
<li>Longitudinal patient registry to assess treatment patterns and outcomes in overactive bladder</li>
<li>Urinary stress incontinence registry in North and South America, Europe, and the Middle East</li>
<li>Design of an economic substudy of a trial in acute urinary retention</li>
<li>Validation study of a premature ejaculation questionnaire</li>
</ul>
<h2>Selected Retrospective Studies </h2>
<ul>
<li>Medicare analysis of complications of surgery for urinary incontinence</li>
<li>Medicare analysis of incidence and costs of skeletal-related events in prostate cancer</li>
<li>Medicare analysis of use of imaging in prostate cancer</li>
<li>Medicare cost comparison of principal treatments for prostate cancer</li>
<li>Multiple Medicare analyses of incontinence and sequelae</li>
<li>Multiple Medicare analyses of prostate cancer treatment and costs</li>
<li>Multiple Medicare analyses of use of prostatectomy and associated clinical and economic outcomes</li>
<li>Claims data analysis of medical treatment for erectile dysfunction</li>
<li>Comparison of racial differences nationwide in the care and cost of prostate cancer</li>
<li>Examination of the relationship of various risk factors and sexual dysfunction</li>
</ul>
<h2>Selected Modeling Studies</h2>
<ul>
<li>Budget impact model for a pharmacotherapy in sexual dysfunction</li>
<li>Budget impact of alternative medicines to manage benign prostatic hyperplasia</li>
<li>Cost-effectiveness model in benign prostatic hyperplasia</li>
<li>Cost-effectiveness model of a treatment for urinary incontinence</li>
<li>Cost-effectiveness model of prostate cancer prevention</li>
<li>Economic model in overactive bladder</li>
<li>Risk assessment model for sexual dysfunction</li>
</ul>
<h2>Selected Publications & Presentations of ABS Team Members</h2>
<p>Hu JC, Wang Q, Pashos CL, et al. Utilization and outcomes of minimally invasive radical prostatectomy. J Clin Oncol 2008; 26 (14): 2278-84.</p>
<p>Anger JT, Litwin MS, Wang Q, Pashos CL, et al. Variations in stress incontinence and prolapse management by surgeon specialty. J Urol 2007; 178(4): 1411-7.</p>
<p>Anger JT, Rodriguez LV, Wang Q, Pashos CL, Litwin MS. The role of pre-operative testing on outcomes after sling surgery for stress urinary incontinence. J Urol 2007; 178(4): 1364-9.</p>
<p>Anger JT, Litwin MS, Wang Q, Pashos CL, et al. The effect of age on outcomes after sling surgery for urinary incontinence. J Am Geriatr Soc 2007; 55(12): 1927-31.</p>
<p>Anger JT, Rodriguez LV, Wang Q, Chen E, Pashos CL, Litwin MS. Racial disparities in the surgical management of stress incontinence among female Medicare beneficiaries. J Urol 2007; 177(5): 1846-50.</p>
<p>Anger JT, Rodríguez LV, Wang Q, Pashos CL, Litwin MS. The role of provider volume on outcomes after sling surgery for stress urinary incontinence. J Urol 2007; 177(4): 1457-62.</p>
<p>Anger JT, Litwin MS, Wang Q, Pashos CL, Rodriguez LV. Complications of sling surgery among female Medicare beneficiaries. Obstet Gynecol 2007; 109(3): 707-14.</p>
<p>Anger JT, Litwin MS, Wang Q, Pashos CL, Rodríguez LV. Variations in stress incontinence and prolapse management by surgeon specialty. Journal of Urology 2006; 175(4): 293. American Urological Association (AUA), Annual Meeting, Atlanta, GA, May 20-25, 2006.</p>
<p>Smith MR, Lee WC, Brandman J, Wang Q, Botteman M, Pashos CL. Gonadrotropin-releasing hormone agonists and fracture risk: A claims-based cohort study of men with nonmetastatic prostate cancer. J Clin Oncol 2005; 23(31): 7897-903.</p>
<p>Krupski TL, Smith MR, Lee WC, Pashos CL, Brandman J, Wang Q, Botteman M, Litwin MS. Natural history of bone complications in men with prostate carcinoma initiating androgen deprivation therapy. Cancer 2004; 101(3): 541-9.</p>
<p>Botteman MF, Pashos CL, Redaelli A, Laskin B, Hauser R. The health economics of bladder cancer: A comprehensive review of the published literature. Pharmacoeconomics 2003; 21(18): 1315-30.</p>
<p>Botteman MF, Pashos CL, Hauser RS, Laskin BL, Redaelli A. Quality of life aspects of bladder cancer: A review of the literature. Qual Life Res 2003; 12(6): 675-88.</p>
<p>Krupski T, Smith M, Lee WC, Pashos CL, Brandman J, Wang Q, Botteman M, Litwin M. Fracture risk in men with prostate cancer on androgen deprivation therapy. AUA, Annual Meeting, Chicago, IL, April 26 - May 3, 2003.</p>
<p>Hu JC, Gold KF, Pashos CL, Mehta SS, Litwin MS. Temporal trends in radical prostatectomy complications from 1991-1998. J Urol 2003; 169(4): 1443-8.</p>
<p>Saigal CS, Pashos CL, Henning JM, Litwin MS. Variations in use of imaging in a national sample of men with early stage prostate cancer. Urology 2002; 59(3): 400-4.</p>
<p>Pashos CL, Botteman MF, Laskin BL, Redaelli A. Bladder cancer: epidemiology, diagnosis, and management. Cancer Pract 2002; 10(6): 311-22.</p>
<p>Boone TB, Kusek JW, Nyberg LM, Steele G, Pashos CL, Grossman M, Diokno A, Bull S, Albrecht D. Treatment patterns and associated symptom improvement during six months of care for overactive bladder: a prospective, observational study. Clin Ther 2002; 24(3): 397-408.</p>
<p>Hu JC, Gold KF, Pashos CL, Mehta SS, Litwin MS. Role of surgeon volume in radical prostatectomy outcomes. J Clin Oncol 2003; 21(3): 401-5.</p>
<p>Diokno A, Lee P, Zorn BH, Lenderking WR, Grossman MA, Bull SA, Albrecht D. Factors associated with clinical assessment of overactive bladder and selection of treatment. Clin Ther 2001; 23(9): 1542-51.</p>
<p>Brandeis J, Pashos CL, Henning JM, Litwin MS. Racial differences in the cost of treating men with early-stage prostate cancer. J Am Geriatr Soc 2001; 49(3): 297-303.</p>
<p>Brandeis J, Pashos CL, Henning JM, Litwin MS. A nationwide charge comparison of the principal treatments for early stage prostate cancer. Cancer 2000; 89(8): 1792-9.</p>
<p>Lenderking WR, Sweeney SL, Pashos CL, Flanders SC. The need for a quality of life instrument for erectile dysfunction: a systematic review of the literature. Value Health 2000; 3: 98.</p>
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