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<h1>Systematic Literature Syntheses <br />
and Reviews </h1>
<p>The ABS team has extensive experience developing literature syntheses in multiple therapeutic areas. Examples of this work are presented here.</p>
<h2>Cardiovascular and Metabolic Diseases</h2>
<ul>
<li>Effect of beta blockers on health-related quality of life (HRQL) in patients with congestive heart failure</li>
<li>Economic and clinical value of fixed-dose combination therapy in hypertension</li>
<li>Socioeconomic characteristics of diabetes special populations </li>
<li>Compliance with treatment and diet/exercise programs in diabetes and obesity</li>
<li>Epidemiology, treatment patterns, and outcomes for open and minimally-invasive surgery for mitral valve regurgitation and aortic stenosis</li>
</ul>
<h2>Gastrointestinal Conditions</h2>
<ul>
<li>Treatment of irritable bowel syndrome</li>
</ul>
<h2>Infectious Disease</h2>
<ul>
<li>Economic and HRQL data for an antibiotic</li>
<li>Epidemiology and clinical outcomes of Staphylococcus aureus infections in selected surgery populations</li>
<li>Economic issues in hepatitis C </li>
<li>Clinical and economic issues in cachexia associated with acquired immune deficiency syndrome (AIDS)</li>
<li>Economic and HRQL burden of needlestick injuries</li>
<li>Economic value of blood safety in transfusion</li>
</ul>
<h2>Musculoskeletal Conditions<br />
</h2>
<ul>
<li>Clinical, economic, and HRQL burden of rheumatoid arthritis (RA) and osteoarthritis</li>
<li>Osteoporosis and breast cancer and their concomitant occurrence </li>
<li>Clinical, functional, and HRQL burden of illness of a rare pediatric genetic disorder with orthopedic complications</li>
<li>Use of devices in orthopedic surgery</li>
<li>Pain control provided by oral opioids</li>
</ul>
<h2>Neurology/Psychiatry</h2>
<ul>
<li>Economic and HRQL burden of restless legs syndrome</li>
<li>Economic and HRQL issues in schizophrenia</li>
<li>Economic and HRQL topics in Parkinson’s disease</li>
<li>Development of dependence on insomnia medications</li>
<li>Epidemiology of epilepsy</li>
</ul>
<h2>Oncology</h2>
<ul>
<li>Economic and HRQL burden of chemotherapy-induced nausea and vomiting</li>
<li>Assessment of patient-reported outcomes in breast, prostate, pancreatic, and colorectal cancer</li>
<li>Use of maintenance therapy in ovarian cancer</li>
<li>Clinical issues in iron chelation for iron-overloaded patients with myelodysplastic syndromes</li>
<li>Clinical and economic issues in cancer cachexia</li>
<li>Clinical, economic and HRQL burden of cancer pain</li>
<li>Treatment and prevention of breast cancer and osteoporosis in post-menopausal women</li>
<li>Adherence to National Comprehensive Cancer Network (NCCN) Guidelines for breast, colon, and rectal cancers</li>
<li>Multiple reviews in bladder cancer, breast cancer, chemotherapy-induced peripheral neuropathy, follicular non-Hodgkin’s lymphoma, gastrointestinal stromal tumor, head and neck cancer, leukemia, melanoma, and renal cell cancer</li>
<li>Multiple reviews of HRQL and other patient-reported outcomes in breast cancer, colorectal cancer, pancreatic, prostate, and renal cell cancer</li>
</ul>
<h2>Ophthalmology</h2>
<ul>
<li>Clinical, economic, and HRQL burden of dry eye syndrome</li>
</ul>
<h2>Urology</h2>
<ul>
<li>Clinical, economic, and HRQL burden of bladder cancer</li>
<li>Epidemiology, diagnosis, and management of bladder cancer</li>
<li>Patient and partner HRQL in sexual function</li>
</ul>
<h2>Women's Health</h2>
<ul>
<li>Clinical, economic, and HRQL burden of endometriosis</li>
<li>Treatment and prevention of breast cancer and osteoporosis in post- menopausal women</li>
</ul>
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