|
Server : Apache/2.4.62 System : FreeBSD fbsdweb2.web.rcn.net 14.1-RELEASE FreeBSD 14.1-RELEASE releng/14.1-n267679-10e31f0946d8 GENERIC amd64 User : www ( 80) PHP Version : 8.3.8 Disable Function : NONE Directory : /domains/bluerae/clients/abs/advantage/ |
Upload File : |
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
<html xmlns="http://www.w3.org/1999/xhtml">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8" />
<title>Rare Diseases: ABS Abt Bio-Pharma Solutions</title>
<script language="javascript" type="text/javascript" src="../scripts/scripts.js"></script>
<link href="../styles/styles.css" rel="stylesheet" type="text/css" />
</head>
<body onload="P7_autoHide('popupabout','popupadvantage','popupservices','popuppub','popupnews','popupcareers');MM_preloadImages('../images/thumb1_ovr.jpg','../images/thumb2_ovr.jpg','../images/thumb3_ovr.jpg','../images/ba_about.gif','../images/ba_advantage.gif','../images/ba_services.gif','../images/ba_pub.gif','../images/ba_news.gif','../images/ba_careers.gif')">
<div id="container">
<!--HEADER-->
<div id="header" onmouseover="P7_autoLayers(0)"><p><a href="../index.html"><img src="../images/logo.gif" alt="ABS: Abt Bio-Pharma Solutions" width="284" height="85" id="logo" /></a><a href="../index.html">home</a> :: <a href="../about/our.html">contact us</a> :: <a href="../search/index.html">search</a> :: <a href="../sitemap/index.html">sitemap</a></p>
<img src="../images/tagline.gif" alt="Real World. Real Value." width="240" height="20" class="tagline" />
</div>
<!--MAIN MENU-->
<div id="mainmenu"><img src="../images/menu_cap.gif" alt=" " onmouseover="P7_autoLayers(0)" /><a href="#" onmouseout="MM_swapImgRestore()" onmouseover="MM_swapImage('about','','../images/ba_about.gif',1)"><img src="../images/b_about.gif" alt="About Us" name="about" width="81" height="35" border="0" id="about" onmouseover="P7_autoLayers(0,'popupabout');P7_Snap('about','popupabout',0,35)" /></a><a href="#" onmouseout="MM_swapImgRestore()" onmouseover="MM_swapImage('advantage','','../images/ba_advantage.gif',1)"><img src="../images/ba_advantage.gif" alt="ABS Advantage" name="advantage" width="123" height="35" border="0" id="advantage" onmouseover="P7_autoLayers(0,'popupadvantage');P7_Snap('advantage','popupadvantage',0,35)" /></a><a href="#" onmouseout="MM_swapImgRestore()" onmouseover="MM_swapImage('services','','../images/ba_services.gif',1)"><img src="../images/b_services.gif" alt="Services" name="services" width="81" height="35" border="0" id="services" onmouseover="P7_autoLayers(0,'popupservices');P7_Snap('services','popupservices',0,35)" /></a><a href="#" onmouseout="MM_swapImgRestore()" onmouseover="MM_swapImage('pub','','../images/ba_pub.gif',1)"><img src="../images/b_pub.gif" alt="Publications & Presentations" name="pub" width="221" height="35" border="0" id="pub" onmouseover="P7_autoLayers(0,'popuppub');P7_Snap('pub','popuppub',0,35)" /></a><a href="#" onmouseout="MM_swapImgRestore()" onmouseover="MM_swapImage('news','','../images/ba_news.gif',1)"><img src="../images/b_news.gif" alt="News & Events" name="news" width="120" height="35" border="0" id="news" onmouseover="P7_autoLayers(0,'popupnews');P7_Snap('news','popupnews',0,35)" /></a><a href="#" onmouseout="MM_swapImgRestore()" onmouseover="MM_swapImage('careers','','../images/ba_careers.gif',1)"><img src="../images/b_careers.gif" alt="Careers" name="careers" width="80" height="35" border="0" id="careers" onmouseover="P7_autoLayers(0,'popupcareers');P7_Snap('careers','popupcareers',0,35)" /></a><img src="../images/menu_cap.gif" alt=" " /></div>
<div id="sidebarleft"><div id="pagemenu">
<ul>
<li><a href="index.html">Our Advantage</a></li>
<li><a href="approach.html">Approach</a></li>
<li><a href="experience.html">Experience</a>
<ul>
<li><a href="exp_allergy.html">Allergy & Respiratory Diseases </a></li>
<li><a href="exp_cardio.html">Cardiovascular Diseases </a></li>
<li><a href="exp_diabetes.html">Diabetes </a></li>
<li><a href="exp_diagnostics.html">Diagnostics Research</a></li>
<li><a href="exp_endocrinology.html">Endocrinology </a></li>
<li><a href="exp_gastro.html">Gastroenterology & Otolaryngology </a></li>
<li><a href="exp_infectious.html">Infectious Diseases </a></li>
<li><a href="exp_medical.html">Medical Device Research</a></li>
<li><a href="exp_musculo.html">Musculoskeletal & Connective Tissue Disorders </a></li>
<li><a href="exp_neurology.html">Neurology & Psychiatry </a></li>
<li><a href="exp_oncology.html">Oncology </a></li>
<li><a href="exp_ophthalmology.html">Ophthalmology </a></li>
<li><a href="exp_rare.html" class="selected">Rare Diseases </a></li>
<li><a href="exp_urology.html">Urology </a></li>
<li><a href="exp_womens.html">Women's Health</a></li>
</ul>
</li>
</ul>
</div>
</div>
<!-- SIDEBAR -->
<div id="sidebar"><form action="http://search.freefind.com/find.html" method="get" accept-charset="utf-8" target="_self">
<p>
<input type="hidden" name="si" value="49467390">
<input type="hidden" name="pid" value="r">
<input type="hidden" name="n" value="0">
<input type="hidden" name="_charset_" value="">
<input type="hidden" name="bcd" value="÷">
<input type="text" name="query" class="searchfield" onfocus="clearText(this);clearStyle(this);" value="SEARCH" size="20">
<input type="image" name="submit" id="submit" src="../images/go.gif" /> </p>
</form><h1 class="sidebarhead"> </h1>
<h1 class="sidebarhead">Download</h1>
<ul class="sidebarlist">
<li><a href="../downloads/ABS_HERQuLES_Medicare.pdf">Experience in Medicare Data Analysis</a></li>
<li><a href="../downloads/ABS_HERQuLES_HRQL.pdf">Health-Related Quality of Life & Patient Reported Outcomes</a></li>
<li><a href="../downloads/ABS_HERQuLES_Modeling.pdf">Modeling Experience</a></li>
<li><a href="../downloads/ABS_Registries.pdf">Registries</a></li>
<li><a href="../downloads/ABS_HERQuLES_StrategicReimb.pdf">Strategic Reimbursement Planning & Support</a></li>
<li><a href="../downloads/ABS_HERQuLES_LitReview.pdf">Systematic Literature Synthesis & Reviews</a></li>
<li><a href="../downloads/ABS_HERQuLES_RealWorld.pdf">Understanding the Real World Via Retrospective Analysis</a></li>
</ul>
</div>
<!-- MAIN CONTENT -->
<div id="maincontent">
<h1>Rare Diseases</h1>
<p>The ABS team has extensive experience conducting various strategic and tactical, prospective and retrospective research and consulting services in rare diseases. Examples of this work are presented here.</p>
<h2>Indications</h2>
<ul>
<li>Acromegaly</li>
<li>Crohn’s disease</li>
<li>Cystic fibrosis</li>
<li>Fabry disease</li>
<li>Gastrointestinal stromal tumor (GIST)</li>
<li>Growth hormone deficiency</li>
<li>Hemophilia</li>
<li>Leukemias (different types)</li>
<li>Mucopolysaccharidosis (MPS) I <br />
- Hurler, Hurler-Scheie, and Scheie diseases</li>
<li>MPS II / Hunter syndrome</li>
<li>Myelodysplastic syndrome</li>
<li>Niemann-Pick disease</li>
<li>Post-transplant lymphoproliferative disorder</li>
<li>Precocious puberty</li>
<li>Preeclampsia</li>
<li>Renal cell carcinoma (RCC)</li>
</ul>
<h2>Strategic Consulting and Research Examples</h2>
<ul>
<li>AMCP-compliant dossiers in renal cell carcinoma </li>
<li>Economic reimbursement support dossier in leukemia</li>
<li>Global conference on economics of rare diseases</li>
<li>Global pricing in chronic myeloid leukemia and GIST</li>
<li>Health-related quality of life (HRQL) assessment strategy in growth hormone deficiency</li>
<li>NICE dossier in metastatic renal cell cancer with adaptation for other markets </li>
<li>Numerous systematic reviews in various rare solid and blood cancers</li>
<li>Publication planning in RCC and GIST</li>
<li>Strategic communication on the burden of Hurler / Hurler-Scheie / Scheie diseases</li>
<li>Strategic market entry strategy for a renal disease complication</li>
<li>Study of physician and patient perspectives for hemophilia and its treatments</li>
<li>Systematic reviews in myelodysplastic syndrome and preeclampsia</li>
</ul>
<h2>Selected Prospective Studies</h2>
<ul>
<li>Assessment of clinical, economic, and HRQL burden of Fabry disease</li>
<li>Data management for six cystic fibrosis clinical trials</li>
<li>Design of patient registry in Crohn’s disease </li>
<li>Economic piggy-back evaluation in leukemia clinical trial </li>
<li>Epidemiology study of cystic fibrosis</li>
<li>HRQL and productivity assessment in subset of patients with hemophilia</li>
<li>HRQL assessment in Hunter syndrome</li>
<li>HRQL instrument development and validation in MPS II / Hunter syndrome</li>
<li>HRQL instrument validation in acromegaly</li>
<li>Natural history study in Niemann-Pick disease in North America, Europe, and the Middle East</li>
<li>Natural history study of Fabry disease</li>
<li>Phase I study of a growth hormone for short stature in children</li>
<li>Phase IIIb study of growth hormone for acromegaly</li>
<li>Phase III study of a growth hormone antagonist for precocious puberty </li>
<li>Phase IV clinical trial in a rare thyroid disorder</li>
<li>Pivotal clinical trials in MPS</li>
<li>Registry programs in growth hormone (pediatric), adult chronic myeloid leukemia, renal cell carcinoma, and autologous knee replacement</li>
</ul>
<h2>Selected Retrospective Studies and Modeling Studies</h2>
<ul>
<li>Analysis of outcomes and costs of patients treated with growth hormone</li>
<li>Analysis of trends and treatment patterns in central precocious puberty</li>
<li>Analysis of health outcomes and costs of patients treated with a growth hormone</li>
<li>Assessment of trends and treatment patterns in central precocious puberty among commercially insured individuals</li>
<li>Cost of illness studies for Fabry disease and MPS I</li>
<li>Cost-effectiveness analysis of vaccine to prevent post-transplant lymphoproliferative disorder</li>
<li>Cost-effectiveness of treatments for RCC </li>
<li>Economic models in RCC for several markets in North America and Europe</li>
</ul>
<h2>Selected Publications & Presentations of ABS Team Members</h2>
<p>Lee WC, Joshi AV, Wolford S, Sumner M, Brown M, Hadker N, Pashos CL. Physicians’ preferences towards coagulation factor concentrates in the treatment of Haemophilia with inhibitors: A discrete choice experiment. Haemophilia 2008; 14(3): 454-65.</p>
<p>Gupta K, Miller JD, Li JZ, Russell MW, Charbonneau C. Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review. Cancer Treat Rev 2008; 34(3): 193-205.</p>
<p>Gao X, Reddy P, Dhanda R, Gondek K, Yeh YC, Stadler WM, Jonasch E. Cost-effectiveness of sorafenib versus best supportive care in advanced renal cell carcinoma. American Society of Clinical Oncology, Annual Meeting, Atlanta, GA, June 2-6, 2006. </p>
<p>Madison MT, Finegan Y, et al. Implementing natural history studies in rare diseases: The Niemann-Pick experience with rapidly changing national regulations in Europe and the Middle East. International Society for Pharmacoeconomics and Outcomes Research, 9th Annual European Congress, Copenhagen, Denmark, October 30, 2006.</p>
<p>Joshi AV, Munro V, Russell MW. Cost-utility of somatropin (rDNA origin) in the treatment of growth hormone deficiency in children. Curr Med Res Opin 2006; 22(2): 351-57.</p>
<p>Lang K, Earle CC , Foster T, et al. Trends in treatment of acute myeloid leukemia in the elderly. Drugs Aging 2005; 22(11): 943-55. </p>
<p>Stephens JM, Gramegna P, Laskin B, Botteman MF, Pashos CL. Chronic lymphocytic leukemia: Economic burden and quality of life: Literature review. Am J Ther 2005; 12(5): 460-6.</p>
<p>Redaelli A, Laskin BL, Stephens JM, Botteman MF, Pashos CL. A systematic literature review of the clinical and epidemiological burden of acute lymphoblastic leukemia. Eur J Cancer Care 2005; 14(1): 53-62. </p>
<p>Redaelli A, Laskin BL, Stephens JM, Botteman MF, Pashos CL. The clinical and epidemiological burden of chronic lymphocytic leukaemia. Eur J Cancer Care 2004; 13: 279-87. </p>
<p>Redaelli A, Botteman MF, Stephens JM, Brandt S, Pashos CL. Economic burden of acute myeloid leukemia: a literature review. Cancer Treat Rev 2004; 30(3): 237-47.</p>
<p>Redaelli A, Bell C, Casagrande J, Stephens J, Botteman M, Laskin B, Pashos CL. Clinical and epidemiologic burden of chronic myelogenous leukemia. Expert Rev Anticancer Ther 2004; 4(1): 85-96. </p>
<p>Redaelli A, Stephens JM, Brandt S, Botteman MF, Pashos CL. Short and long-term effects of acute myeloid leukemia on patient health-related quality of life. Cancer Treat Rev 2004; 30(1): 103-17. </p>
<p>Lee JM, Turini M, Botteman MF, Stephens JM, Pashos CL. Economic burden of head and neck cancer: a literature review. Eur J Health Econ 2004; 5(1): 70-80.</p>
<p>Redaelli A, Lee JM, Stephens JM, Pashos CL. The epidemiology and clinical burden of acute myeloid leukemia. Expert Rev Anticancer Ther 2003; 3(5): 695-710. </p>
<p>Redaelli A, Stephens JM, Laskin BL, Pashos CL, et al. The burden and outcomes associated with four leukemias: AML, ALL, CLL and CML. Expert Rev Anticancer Ther 2003; 3(3): 311-29. </p>
<p>Gold KF, Pastores GM, Botteman MF, Yeh JM, Sweeney S, Aliski W, Pashos CL. Quality of life of patients with Fabry disease. Qual Life Res 2002; 11(4): 317-27.</p>
<p>Lenderking WR, Zacker C, Katznelson L, Vance ML, Hossain S, Tafesse E, Guacaneme AO , Pashos CL. The reliability and validity of the impact on lifestyle questionnaire in patients with acromegaly. Value Health 2000; 3(4): 261-69.</p>
</div>
<!-- FOOTER -->
<div id="footer">
© 2009 Abt Bio-Pharma Solutions, Inc. All rights reserved. | <a href="../privacy/index.html">Privacy Statement</a> | <a href="../privacy/safe.html">Safe Harbor Policy</a></div>
</div><!--close container-->
<!-- POPUP MENUS -->
<div id="popupabout" class="popupmenu">
<p><a href="../about/index.html">About ABS</a></p>
<p><a href="../about/executive.html">Executive Management</a></p>
<p><a href="../about/our.html">Our Locations</a></p></div>
<div id="popupadvantage" class="popupmenu">
<p><a href="../advantage/index.html">Our Advantage</a></p>
<p><a href="../advantage/approach.html">Approach</a></p>
<p><a href="../advantage/experience.html">Experience</a></p></div>
<div id="popupservices" class="popupmenu">
<p><a href="../services/biometrics.html">Biometrics</a></p>
<p><a href="../services/clinical.html">Clinical Trials</a></p>
<p><a href="../services/health.html">Health Economics & Outcomes Research</a></p>
<p><a href="../services/postmarketing.html">Registries and Observational Studies</a></p>
<p><a href="../services/strategic.html">Strategic Commercialization Services</a></p></div>
<div id="popuppub" class="popupmenu">
<p><a href="../pub/publications.html">Publications</a></p>
<p><a href="../pub/presentations.html">Presentations</a></p></div>
<div id="popupnews" class="popupmenu">
<p><a href="../news/index.html">News</a></p>
<p><a href="../news/events.html">Events</a></p></div>
<div id="popupcareers" class="popupmenu">
<p><a href="../careers/index.html">Employment at ABS</a></p>
<p><a href="../careers/current.html">Current Opportunities</a></p>
<p><a href="../careers/benefits.html">Benefits</a></p></div>
<script type="text/javascript">
var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www.");
document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E"));
</script>
<script type="text/javascript">
try {
var pageTracker = _gat._getTracker("UA-7436309-1");
pageTracker._trackPageview();
} catch(err) {}</script>
</body>
</html>