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<h1>Oncology</h1>
<p>The ABS team has extensive experience conducting various strategic and tactical, prospective and retrospective research and consulting services in oncology and hematology. Examples of this work are presented here.</p>
<h2>Indications</h2>
<ul>
<li>Bladder cancer</li>
<li>Bone complications of cancer</li>
<li>Breast cancer</li>
<li>Cancer-related cachexia</li>
<li>Cervical cancer</li>
<li>Chemotherapy-induced; anemia, nausea and vomiting (CINV), peripheral neuropathy (CIPN), thrombocytopenia (CIT)</li>
<li>Colorectal cancer (CRC)</li>
<li>Gastric cancer</li>
<li>Gastrointestinal stromal tumor (GIST)</li>
<li>Head and neck cancer</li>
<li>Hemophilia</li>
<li>Hodgkin’s and non-Hodgkin’s lymphoma</li>
<li>Idiopathic thrombocytopenic purpura</li>
<li>Leukemia</li>
<li>Lung cancer</li>
<li>Lymphoma</li>
<li>Melanoma</li>
<li>Myelodysplastic syndrome</li>
<li>Ovarian cancer</li>
<li>Pancreatic cancer</li>
<li>Prostate cancer</li>
<li>Renal cell cancer (RCC)</li>
</ul>
<h2>Strategic Consulting and Research Examples</h2>
<ul>
<li>NICE dossier in metastatic RCC with adaptation for other markets</li>
<li>Global value dossier in solid cancer with adaptation for NICE</li>
<li>Dossiers for complications of cancer and bone metastases</li>
<li>Dossier in chronic leukemia</li>
<li>Value dossier in cancer-related cachexia</li>
<li>Global pricing in chronic myeloid leukemia and GIST</li>
<li>Publication planning in RCC and in GIST</li>
<li>Systematic review of adherence to National Comprehensive Cancer Network (NCCN) Guidelines for breast, colon, and rectal cancers</li>
<li>Multiple systematic reviews in bladder cancer, breast cancer, CIPN, follicular non-Hodgkin’s lymphoma, GIST, head and neck cancer, leukemia, melanoma, and RCC</li>
<li>Multiple systematic reviews of HRQL/PRO in breast cancer, CINV, CRC, pancreatic, prostate, and renal cell cancer</li>
<li>Systematic reviews in myelodysplastic syndrome, ovarian cancer, and idiopathic thrombocytopenic purpura</li>
<li>Systematic review of electronic PRO instruments in prostate cancer</li>
</ul>
<h2>Selected Prospective Studies</h2>
<ul>
<li>Patient registries in adult chronic myeloid leukemia and chemotherapy-induced anemia</li>
<li>Registry in RCC in North America, Europe and the Middle East</li>
<li>Outcomes registry in CINV</li>
<li>Study of physician and patient preferences for hemophilia treatments, including HRQL and productivity</li>
<li>Patient and physician surveys of CRC attitudes, awareness, and behavior</li>
<li>Economic piggy-back evaluation in leukemia clinical trial</li>
<li>HRQL and pain assessment in prostate cancer in Phase IV open-label clinical trial</li>
<li>HRQL assessment in ovarian cancer</li>
<li>HRQL and productivity in patients with hemophilia and inhibitors and their caregivers</li>
</ul>
<h2>Selected Retrospective Studies </h2>
<ul>
<li>Multiple analyses of care and clinical and economic outcomes using Medicare data in prostate, breast, and colorectal cancer</li>
<li>Multi-site chart-review-based analysis in CIT</li>
<li>Managed care analyses of cancer-related cachexia and of treatment patterns and outcomes in chemotherapy-induced anemia</li>
<li>Longitudinal Medicare analysis of outcomes following colorectal and general surgery</li>
<li>Medicare analysis of incidence and costs of skeletal-related events in prostate cancer</li>
<li>Multiple literature syntheses in numerous cancers</li>
</ul>
<h2>Selected Modeling Studies</h2>
<ul>
<li>Cost-effectiveness model of vaccination to prevent Hodgkin’s and non-Hodgkin’s lymphoma, post-transplant lymphoproliferative disorders, and gastric cancer</li>
<li>Cost-effectiveness of agents in RCC, prostate cancer and gastric cancer</li>
<li>Economic models in cancer-related cachexia, CRC, and RCC</li>
<li>Economic model for therapy in advanced RCC in Germany</li>
</ul>
<h2>Selected Publications & Presentations of ABS Team Members</h2>
<p>Gupta K, Miller JD, Li JZ, Russell MW, Charbonneau C. Epidemiologic and socioeconomic burden of metastatic renal cell carcinoma (mRCC): a literature review. Cancer Treat Rev 2008; 34(3): 193-205.</p>
<p>Lee WC, Joshi AV, Wolford S, Sumner M, Brown M, Hadker N, Pashos CL. Physicians’ preferences towards coagulation factor concentrates in the treatment of hemophilia with inhibitors: A discrete choice experiment. Haemophilia 2008; 14(3): 454-65.</p>
<p>Hu JC, Wang Q, Pashos CL, et al. Utilization and outcomes of minimally invasive radical prostatectomy. J Clin Oncol 2008; 26(14): 2278-84.</p>
<p>Larholt K, Pashos CL, Wang Q, et al. Dosing and Outcomes Study of Erythropoiesis-stimulating Therapies (DOSE): A registry for characterizing anemia management and outcomes in oncology patients. Clin Drug Investig 2008; 28(3): 159-67.</p>
<p>Gosselin A, Pashos CL, et al. Drug administration frequency and provider office visit patterns for oncology patients during treatment with erythropoietic agents: An analysis of four observational studies. Clin Ther 2006; 28(10): 1701-8.</p>
<p>Komatsuzaki Y, Gramegna P, Stephens JM, Lee JM, Botteman MF, Pashos CL, et al. Preferences and utilities of health outcomes and treatments associated with head and neck cancer: A systematic review. Am J Cancer 2006; 5(1): 27-34.</p>
<p>Smith MR, Lee WC, Brandman J, Wang Q, Botteman M, Pashos CL. Gonadrotropin-releasing hormone agonists and fracture risk: a claims-based cohort study of men with nonmetastatic prostate cancer. J Clin Oncol 2005; 23(31): 7897-903.</p>
<p>Lang K, Earle CC , Foster T, et al. Trends in treatment of acute myeloid leukemia in the elderly. Drugs Aging 2005; 22(11): 943-55.</p>
<p>Straus WL, Mansley EC, Gold KF, Wang Q, Reddy P, Pashos CL. Colorectal cancer screening attitudes and practices in the general population: a risk-adjusted survey. J Public Health Manag Pract 2005; 11(3): 244-51.</p>
<p>Redaelli A, Laskin BL, Stephens JM, Botteman MF, Pashos CL. A systematic literature review of the clinical and epidemiological burden of acute lymphoblastic leukemia. Eur J Cancer Care (Engl) 2005; 14(1): 53-62.</p>
<p>Redaelli A, Laskin BL, Stephens JM, Botteman MF, Pashos CL. The clinical and epidemiological burden of chronic lymphocytic leukaemia. Eur J Cancer Care (Engl) 2004; 13: 279-87.</p>
<p>Redaelli A, Bell C, Casagrande J, Stephens J, Botteman M, Laskin B, Pashos CL. Clinical and epidemiologic burden of chronic myelogenous leukemia. Expert Rev Anticancer Ther 2004; 4(1): 85-96.</p>
<p>Redaelli A, Stephens JM, Brandt S, Botteman MF, Pashos CL. Short and long-term effects of acute myeloid leukemia on patient health-related quality of life. Cancer Treat Rev 2004; 30(1): 103-17.</p>
<p>Lee JM, Turini M, Botteman MF, Stephens JM, Pashos CL. Economic burden of head and neck cancer: a literature review. Eur J Health Econ 2004; 5(1): 70-80.</p>
<p>Botteman MF, Pashos CL, et al. The health economics of bladder cancer: A comprehensive review of the published literature. Pharmacoeconomics 2003; 21(18): 1315-30.</p>
<p>Botteman MF, Pashos CL, et al. Quality of life aspects of bladder cancer: A review of the literature. Qual Life Res 2003; 12(6): 675-88.</p>
<p>Redaelli A, Lee JM, Stephens JM, Pashos CL. The epidemiology and clinical burden of acute myeloid leukemia. Expert Rev Anticancer Ther 2003; 3(5): 695-710.</p>
<p>Hu JC, Gold KF, Pashos CL, et al. Temporal trends in radical prostatectomy complications from 1991-1998. J Urol 2003; 169(4): 1443-48.</p>
<p>Redaelli A, Stephens JM, Laskin BL, Pashos CL, et al. The burden and outcomes associated with four leukemias: AML, ALL, CLL and CML. Expert Rev Anticancer Ther 2003; 3(3): 311-29.</p>
<p>Hu JC, Gold KF, Pashos CL, et al. Role of surgeon volume in radical prostatectomy outcomes. J Clin Oncol 2003; 21(3): 401-5.</p>
<p>Saigal CS, Pashos CL, et al. Variations in use of imaging in a national sample of men with early stage prostate cancer. Urology 2002; 59(3): 400-4.</p>
<p>Pashos CL, et al. Bladder cancer: epidemiology, diagnosis, and management. Cancer Practice 2002; 10(6): 311-22.</p>
<p>Brandeis J, Pashos CL, et al. Racial differences in the cost of treating men with early-stage prostate cancer. J Am Geriatr Soc 2001; 49(3): 297-303.</p>
<p>Brandeis J, Pashos CL, et al. A nationwide charge comparison of the principal treatments for early stage prostate carcinoma. Cancer 2000; 89(8): 1792-9.</p>
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