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<h1>Neurology & Psychiatry</h1>
<p>The ABS team has extensive experience conducting various strategic and tactical, prospective and retrospective research and consulting services in neurology and psychiatry. Examples of this work are presented here.</p>
<h2>Indications</h2>
<ul>
<li>Alzheimer’s disease (AD)</li>
<li>Anxiety disorder</li>
<li>Autism</li>
<li>Bipolar disorder (BPD)</li>
<li>Dementia</li>
<li>Depression</li>
<li>Epilepsy</li>
<li>Insomnia</li>
<li>Migraine</li>
<li>Multiple sclerosis (MS)</li>
<li>Pain (acute and chronic)</li>
<li>Parkinson’s disease (PD)</li>
<li>Restless legs syndrome (RLS)</li>
<li>Schizophrenia</li>
<li>Vascular dementia</li>
</ul>
<h2>Strategic Consulting and Research Examples</h2>
<ul>
<li>Clinical, economic, and HRQL systematic review of cancer pain and strategic outcomes research plan</li>
<li>Comprehensive strategic outcomes research plan for pain treatment in multiple indications</li>
<li>Economic and HRQL systematic reviews of PD, RLS, and schizophrenia</li>
<li>Global economic environment assessment in insomnia</li>
<li>Global pricing research in PD</li>
<li>Reimbursement support and response documents in AD and schizophrenia</li>
<li>Reimbursement support dossier in AD</li>
<li>Strategic outcomes research and communication package for opioid analgesic in non-cancer indications</li>
<li>Strategic outcomes research in chronic pain and migraine</li>
<li>Strategic review of patient- and caregiver-reported instruments in AD</li>
<li>Systematic review of epidemiology of epilepsy</li>
<li>Systematic review in chronic pain</li>
</ul>
<h2>Selected Prospective Studies</h2>
<ul>
<li>Registry programs in addiction, chronic progressive MS, neuropathic and postoperative pain, and schizophrenia</li>
<li>Study of treatment effectiveness in depression</li>
<li>Clinical trial assessing post-operative pain and associated outcomes</li>
<li>Phase II trial in insomnia</li>
<li>Phase IIIb economic and HRQL trial in anesthesia and pain management</li>
<li>Analysis and reporting of the economic component of a Phase III trial in dementia</li>
<li>Economic analyses of a Phase III trial in AD</li>
<li>HRQL and economic components of a trial in epilepsy</li>
<li>Selection of PRO measures for Phase II and III clinical trials in insomnia</li>
<li>Assessments of patient preference and willingness to pay for antidepressants</li>
<li>Patient and physician surveys in BPD, including patient preferences for medications and adherence to therapy</li>
<li>Patient survey to position a surgical product to reduce post-surgery pain</li>
</ul>
<h2>Selected Retrospective Studies </h2>
<ul>
<li>Analyses of pain management and costs in cancer and non-cancer indications using managed care claims and medical chart data</li>
<li>Analysis of resource use and costs of caregivers in AD and related dementias</li>
<li>Managed care analyses of diabetic peripheral neuropathic pain, treatment compliance and persistence in AD, and treatments and associated costs in epilepsy</li>
</ul>
<h2>Selected Modeling Studies</h2>
<ul>
<li>Comprehensive cost-effectiveness analysis of an analgesic</li>
<li>Cost-effectiveness analysis of an antidepressant and other antidepressants for acute major depressive disorder</li>
<li>Cost-effectiveness models in depression, insomnia, and schizophrenia</li>
<li>Cost-effectiveness model of antidepressant vs. standard therapy in managed care</li>
<li>Cost-effectiveness of various triptans in the treatment of migraine</li>
<li>Economic models in outpatient pain management and MS</li>
<li>Economic pricing models in epilepsy, neuropathic pain, and PD</li>
<li>Model in clinically isolated syndrome</li>
<li>Model of pain management care and costs in multiple cancer and non-cancer indications in an HMO</li>
<li>Cost-effectiveness and budget impact models in major depressive disorder</li>
<li>Cost-effectiveness and budget impact models in generalized anxiety disorder</li>
<li>Economic models of MS in Australia and U.S.</li>
</ul>
<h2>Selected Publications & Presentations of ABS Team Members</h2>
<p>Thomson WW, Price C, Goodson B, et al. Early thimerosal exposure and neuropsychological outcomes at 7 to 10 years. NEJM 2007; 357(13): 1281-92.</p>
<p>Botteman MF, Ozminkowski RJ, Wang S, Pashos CL, Schaefer K, Foley DJ. Cost effectiveness of long-term treatment with eszopiclone for primary insomnia in adults: A decision analytical model. CNS Drugs 2007; 21(4): 319-34.</p>
<p>Ganz ML. The lifetime distribution of the incremental societal costs of autism. Arch Pediatr Adolesc Med 2007; 161(4): 343-9.</p>
<p>Ganz M, Tendulkar SA. Mental health care services for children with special health care needs and their family members: Prevalence and correlates of unmet needs. Pediatrics 2006; 117(6): 2138-48.</p>
<p>Lee WC, Hoffman MS, Arcona S, D’Souza J, Wang Q, Pashos CL. A cost comparison of alternative regimens for treatment-refractory partial seizure disorder: An econometric analysis. Clin Ther 2005; 27(10): 1629-38.</p>
<p>Russell MW, Miller JD, Neumann PJ, Menzin J, Boyle ME, Rublee DA. A U.S. pharmacoeconomic model of parenteral parecoxib vs. opioid and ketorolac analgesia following major surgery. Pharmacotherapy 2005; 25(10): 1490.</p>
<p>Lee WC, Arcona S, Thomas SK, Wang Q, Hoffmann MS, Pashos CL. Effect of comorbidities on medical care use and cost among refractory patients with partial seizure disorder. Epilepsy Behav 2005; 7(1): 123-6.</p>
<p>Miller JD, Russell MW, Neumann PJ, Menzin J, Rublee DA, Boye ME. A U.K. pharmacoeconomic model of parenteral parecoxib vs. opioid analgesia following major surgery. Value Health 2005; 8(6): A141.</p>
<p>Mauskopf JA, Paramore C, Lee WC, Snyder EH. Drug persistency patterns for patients treated with rivastigmine or donepezil in usual care settings. J Manag Care Pharm 2005; 11(3): 231-51.</p>
<p>Edwards NC, Rupnow MF, Pashos CL, Botteman MF, Diamond RJ. Cost-effectiveness model of long acting risperidone in schizophrenia in the US. Pharmacoeconomics 2005; 23(3): 299-314.</p>
<p>Brown JS, Papadopoulos G, Neumann PJ, Friedman M, Miller JD, Menzin J. Cost-effectiveness of topiramate in migraine prevention. Headache 2005; 45: 1012-22.</p>
<p>Stephens JM, Pashos CL, Haider S, Wong JM. Making progress in the management of postoperative pain: A review of cyclooxygenase-2 specific inhibitors. Pharmacotherapy 2004; 24(12): 1714-31.</p>
<p>Stephens J, Laskin B, Pashos CL, Pena B, Wong J. The burden of acute postoperative pain and the potential role of the COX-2-specific inhibitors. Rheumatology (Oxford) 2003; 42 Suppl 3: III 40-III 52.</p>
<p>Menzin J, Boulanger L, Friedman M, Mackell J, Lloyd JR. Treatment adherence associated with conventional and atypical antipsychotics in a large state Medicaid program. Psychiatr Serv 2003; 54: 719–23.</p>
<p>Gold KF, Botteman MF, Kemp R, Wang Q, Kittner B, Pashos CL. The impact of dementia on caregiver quality of life. International Society for Pharmacoeconomics and Outcomes Research, 6th Annual Meeting, Arlington, VA, May 20-23, 2001.</p>
<p>Lenderking W, Pashos CL, Haskell L. Controlled-release oxycodone in chronic back pain: A cost analysis in an HMO population. 9th World Congress on Pain, August 25, 1999, Vienna, Austria.</p>
<p>Kahanovitz N, Pashos CL. The role of implantable direct current stimulation in the critical pathway for lumbar spinal fusion. North American Spine Society, 11th Annual Conference, Vancouver, B.C., Canada, October 25, 1996.</p>
<p>Kahanovitz N, Pashos CL. The role of implantable direct current stimulation in the critical pathway for lumbar spinal fusion. J Care Management 1996; 2(6): 46-58.</p>
<p>Oster G, Huse DM, Adams SF, Imbimbo J, Russell MW. Benzodiazepine tranquilizers and the risk of accidental injury. Am J Public Health 1990; 80: 1467-70.</p>
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