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<h1>Musculoskeletal & Connective Tissue Disorders</h1>
<p>The ABS team has extensive experience conducting various strategic and tactical, prospective and retrospective research and consulting services in musculoskeletal and connective tissue disorders. Examples of this work are presented here.</p>
<h2>Indications</h2>
<ul>
<li>Arthritis</li>
<li>Autologous cartilage replacement therapy</li>
<li>Back pain</li>
<li>Hip/knee replacement surgery</li>
<li>Knee arthroscopy</li>
<li>Orthopedic devices</li>
<li>Orthopedic surgery</li>
<li>Osteoarthritis (OA)</li>
<li>Osteoporosis</li>
<li>Rheumatoid arthritis (RA)</li>
<li>Skeletal complications of cancer</li>
</ul>
<h2>Strategic Consulting and Research Examples</h2>
<ul>
<li>Critical review and strategic overview of 30 arthritis clinical trial protocols and findings relevant to economic and health-related quality of life (HRQL) product positioning messages</li>
<li>Functional status instrument review for RA and OA</li>
<li>Literature review of clinical, economic and HRQL issues in RA</li>
<li>Literature review of HRQL and functional status instruments used in a pediatric disorder with orthopedic complications</li>
<li>Literature review of the burden of illness of a rare pediatric genetic disorder with orthopedic complications</li>
<li>Literature review related to use of innovative device in orthopedic surgery</li>
<li>Physician guideline education program and return on investment (ROI) model in arthritis care</li>
<li>Reimbursable environment assessment and strategic marketing recommendations for a new injectable RA agent</li>
<li>Review of the use and outcomes of a new biotechnology product used in orthopedic surgery</li>
<li>Review of utilization and costs of knee arthroscopy</li>
<li>Strategic outcomes research and communication package for an opioid analgesic in back pain</li>
<li>Strategic planning for pain therapy in RA and OA</li>
<li>Systematic reviews of the burden of RA and OA</li>
<li>Systematic review of osteoporosis and breast cancer and their concomitant occurrence</li>
<li>Systematic review of a diagnostic procedure in RA</li>
</ul>
<h2>Selected Prospective Studies</h2>
<ul>
<li>Design of post-marketing experience trial for OA</li>
<li>Global patient registry of patients eligible for autologous cartilage replacement therapy</li>
<li>Longitudinal tracking of patients with an implantable orthopedic device</li>
<li>National Osteoporosis Risk Assessment™ (NORA™) longitudinal patient registry</li>
<li>Patient and physician focus groups of a rare pediatric disorder with orthopedic complications</li>
<li>Validation study of an existing HRQL instrument for use in a rare pediatric disorder with orthopedic complications</li>
</ul>
<h2>Selected Retrospective Studies </h2>
<ul>
<li>Analysis of back pain care and outcomes using medical chart data</li>
<li>Analysis of NHANES to determine the risk of osteoporosis of patient subgroups</li>
<li>Analysis of osteoporosis in Medicaid population</li>
<li>Employer claims analysis of treatment and costs in back pain</li>
<li>Medicare claims data analysis of skeletal related events in patients with prostate cancer</li>
</ul>
<h2>Selected Modeling Studies</h2>
<ul>
<li> Cost-effectiveness model of hormone replacement therapy (HRT) for short-term prevention of osteoporosis</li>
<li>Economic model of early RA in the U.K.</li>
<li>Economic models in RA</li>
<li>Economic model of arthritis treatment from the Veterans’ Affairs health system perspective</li>
<li>Economic models in hip/knee replacement surgery</li>
<li>Markov model of the clinical and economic impact of alternative prevention and treatment regimes for osteoporosis in the U.S. and U.K.</li>
<li>Model of back pain management care and costs in a health maintenance organization (HMO)</li>
</ul>
<h2>Selected Publications & Presentations of ABS Team Members</h2>
<p>Gajria K, Kosinski M, Schein J, Kavanagh S, Dubois D. Health related quality of life outcomes in patients treated with Push-pull OROS hydromorphone versus extended release oxycodone for chronic hip or knee osteoarthritis pain. The Patient: Patient Centered Outcomes Research 2008; in press.</p>
<p>Duff S, Yeh Y, Yu E, Woolley J. The economic impact of etanercept and infliximab treatment in ankylosing spondylitis. European League Against Rheumatism, Annual Congress, Vienna, Austria, July 8-11, 2005.</p>
<p>Schaefer M, DeLattre M, Gao X, Stephens J, Botteman M, Morreale A. Assessing the cost-effectiveness of COX-2 specific inhibitors for arthritis in the Veterans’ Health Administration. Curr Med Res Opin 2005; 21(1): 47-60.</p>
<p>Stephens JM, Pashos CL, Haider S, Wong JM. Making progress in the management of postoperative pain: A review of cyclooxygenase-2 specific inhibitors. Pharmacotherapy 2004; 24(12): 1714-31.</p>
<p>Stephens JM, Bell CF, Wong JM. Value of cyclooxygenase-2 specific inhibitors in the management of osteoarthritis. Expert Rev Pharmacoecon Outcomes Res 2004; 4(4): 441-55.</p>
<p>Krupski TL, Smith MR, Lee WC, Pashos CL, Brandman J, Wang Q, Botteman M, Litwin MS. Natural history of bone complications in men with prostate carcinoma initiating androgen deprivation therapy. Cancer 2004; 101(3): 541-9.</p>
<p>Stephens J, Laskin B, Pashos CL, Pena B, Wong J. The burden of acute postoperative pain and the potential role of the COX-2-specific inhibitors. Rheumatology (Oxford) 2003; 42 Suppl 3: III40-III52.</p>
<p>Singh G, Miller JD, Huse DM, Pettitt D, D’Agostino RB, Russell MW. The consequences of increased systolic blood pressure in patients with osteoarthritis and rheumatoid arthritis. J Rheumatol 2003; 30: 714-719.</p>
<p>Botteman MF, Shah N, Brandman J, Pashos CL. A cost-effectiveness evaluation of two continuous combined hormone replacement therapies for the management of menopausal symptoms and prevention of osteoporosis. North American Menopause Society, 13th Annual Meeting, Chicago, IL, October 4-5, 2002.</p>
<p>Singh G, Miller JD, Lee FH, Pettitt D, Russell MW. Prevalence of cardiovascular disease risk factors among U.S. adults with self-reported osteoarthritis: Data from the Third National Health and Nutrition Examination Survey. Am J Manag Care 2002; 8(15 Suppl): S383-S391.</p>
<p>Comp PC, Miller JD, Mayo KW, Wagner S, Russell MW. Outcomes of dalteparin use following total knee arthroplasty: a retrospective analysis. Expert Rev Pharmacoecon Outcomes Res 2002; 2: 427-34.</p>
<p>Krotenberg R, Adler U, Pomeranz B, Miller JD, Russell MW. Dalteparin vs. enoxaparin as prophylaxis for deep-vein thrombosis after total hip or knee arthroplasty: a retrospective analysis. Am J Phys Med Rehabil 2001; 80: 889-95.</p>
<p>Lenderking W, Pashos CL, Haskell L. Controlled-release oxycodone in chronic back pain: A cost analysis in an HMO population. 9th World Congress on Pain, Vienna, Austria, August 25, 1999.</p>
<p>Pashos CL. The importance of spine outcomes research. Fusions 1997; 6(2): 1-4.</p>
<p>Kahanovitz N, Pashos CL. The role of implantable direct current stimulation in the critical pathway for lumbar spinal fusion. North American Spine Society, 11th Annual Conference, Vancouver, B.C., Canada, October 25, 1996.</p>
<p>Kahanovitz N, Pashos CL. The role of implantable direct current stimulation in the critical pathway for lumbar spinal fusion. J Care Management 1996; 2(6): 46-58.</p>
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