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<h1>Infectious Diseases</h1>
<p>The ABS team has extensive experience conducting various strategic and tactical, prospective and retrospective research and consulting services in infectious diseases. Examples of this work are presented here.</p>
<h2>Indications</h2>
<ul>
<li>Antibiotic resistance</li>
<li>Bacterial pneumonia</li>
<li>Blood safety</li>
<li>Cachexia</li>
<li>Epstein-Barr virus</li>
<li>Hepatitis B and C</li>
<li>Herpes simplex virus</li>
<li>HIV/AIDS</li>
<li>Influenza</li>
<li>Nosocomial pneumonia</li>
<li>Pertussis (whooping cough)</li>
<li>Pneumococcal disease</li>
<li>Respiratory syncytial virus (RSV)</li>
<li>Skin and soft tissue infections</li>
<li>Staphylococcus Aureus infections</li>
<li>Strep. pneumoniae</li>
<li>Tuberculosis</li>
</ul>
<h2>Strategic Consulting and Research Examples</h2>
<ul>
<li>AMCP-compliant dossier for a protease inhibitor in HIV</li>
<li>Burden of illness evaluation of vancomycin in multiple indications (review and manuscript)</li>
<li>Multiple AMCP-compliant dossiers</li>
<li>Strategic value dossier for treatment of cachexia in HIV/AIDS</li>
<li>Strategic global market assessment of tuberculosis vaccine</li>
<li>Strategic planning for an intravenous antibiotic</li>
<li>Strategic outcomes research plan for an antiretroviral therapy in drug resistant HIV/AIDS</li>
<li>Strategic positioning and early economic assessment of adult RSV vaccine in Europe and the United States</li>
<li>Strategic positioning and early economic assessment of Epstein-Barr virus vaccine</li>
<li>Strategic positioning of a herpes simplex virus vaccine</li>
<li>Strategic pricing of two vaccines for infections in the elderly</li>
<li>Strategic pricing and reimbursement intelligence research for pediatric vaccine against Strep. pneumoniae</li>
<li>Systematic review of cachexia in HIV/AIDS</li>
<li>Systematic review of economic and quality of life data on a new antibiotic, to support a formulary submission</li>
<li>Systematic review of the economic value of blood safety in transfusion</li>
<li>Systematic review of the epidemiology and clinical outcomes of Staphylococcus Aureus infections in selected surgery populations</li>
<li>Strategic communications in support of a pneumococcal vaccine</li>
</ul>
<h2>Selected Prospective Studies</h2>
<ul>
<li>Clinical trial assessing patient health related quality of life and utility, medical care utilization and costs and lost productivity, and cost-utility analysis of multiple hepatitis C treatments</li>
<li>Design and analysis of multiple economic substudies within clinical trials of new pharmacotherapy in multiple indications, including skin and soft tissue infections, endocarditis, bacteremia, etc.</li>
<li>Economic component of a clinical trial for a pediatric Strep. pneumoniae vaccine</li>
<li>Economic substudy of a clinical trial of inhaled influenza vaccine</li>
<li>Modification and validation of Health Belief Model instrument to assess HIV patients’ health beliefs and medication adherence</li>
<li>Multiple assessments of interventions to reduce prevalence of HIV/AIDS in China and Vietnam</li>
<li>Patient reported outcomes (PRO) instrument selection for clinical trials of influenza vaccine</li>
</ul>
<h2>Selected Retrospective Studies and Modeling Studies</h2>
<ul>
<li>Analysis of costs of HIV/AIDS</li>
<li>Cost-effectiveness analysis of new blood safety system for patients receiving transfusions</li>
<li>Cost-effectiveness model of Epstein-Barr virus vaccine</li>
<li>Cost-effectiveness model of interferon for chronic hepatitis C</li>
<li>Cost-effectiveness of influenza A vaccine (pandemic model)</li>
<li>Cost-effectiveness of multiple vaccines for the prevention of bacterial pneumonia, pertussis, and RSV</li>
<li>Cost-effectiveness of new antibiotic from hospital perspective in multiple indications</li>
<li>Cost-effectiveness of protease inhibitor for antiretroviral-naïve patients with HIV</li>
<li>Economic model of cachexia in HIV/AIDS</li>
<li>Economic model of hospital-acquired pneumonia</li>
<li>Managed care analysis of cachexia in HIV/AIDS</li>
<li>Model of vaccine for the prevention of Strep. pneumoniae in adults</li>
<li>Multiple economic models of vaccine for the prevention of pertussis in adults and other patient population</li>
</ul>
<h2>Selected Publications & Presentations of ABS Team Members</h2>
<p>Boulanger L, Miller JD, MacEachern L, Reddy P, Russell MW, Pashos CL. Prevalence of cachexia (wasting syndrome) diagnosis and treatment among patients with HIV/AIDS: a medical claims database analysis. International Society for Pharmacoeconomics and Outcomes Research (ISPOR), 12th Annual Meeting, Arlington, VA, May 19-23, 2007.</p>
<p>Koblin BA, Husnik MJ, Colfax G, Huang Y, Madison M, Mayer K, et al. Risk factors for HIV infection among men who have sex with men: The EXPLORE study. AIDS 2006; 20(5): 731-9.</p>
<p>Lee WC, William KW, Chen E, Liu L, Pashos CL. Effects of the ritonavir price increase on the cost of protease inhibitor regimens in the United States. Manag Care Interface 2006; 19(3): 27-32.</p>
<p>Hammett TM, Kling R, Johnston P, et al. Patterns of HIV prevalence and HIV risk behaviors among injection drug users prior to and 24 months following implementation of cross-border HIV prevention interventions in Northern Vietnam and Southern China. AIDS Educ Prev 2006; 18(2): 97-115.</p>
<p>Lee WC. Cost of therapy for ARV Naïve HIV-infected patients: Fosamprenavir/Ritonavir versus Nelfinavir. ISPOR, 10th Annual Meeting, Washington, DC, May 15-18, 2005.</p>
<p>Purdy KW, Hay JW, Botteman MF, Ward JI. Evaluation of strategies for use of a cellular pertussis vaccine in adolescents and adults: A cost-benefit analysis. Clin Infect Dis 2004; 39: 20-8.</p>
<p>Shah NP, Reddy P, Paladino JA, Klepser MA, Pashos CL. Direct medical costs associated with using vancomycin in methicillin-resistant staphylococcus aureus infections: An economic model. Curr Med Res Opin 2004; 20(6): 779-90.</p>
<p>Shah NP, Stephens JM, Lee J, Pashos CL, Graff J, Lenderking WR, Copley-Merriman C. Assessment of economic models of antiretroviral therapies in HIV/AIDS. ISPOR, 7th Annual Meeting, Arlington, VA, May 18-21, 2003.</p>
<p>Bell CF, Botteman MF, Gao X, Weissfeld JL, Postma M, Pashos CL, Triulzi D, Staginnus U. Cost-effectiveness of transfusing platelet components prepared with pathogen inactivation treatment: perspectives from the United States. Clin Ther 2003; 25(9): 2464-86.</p>
<p>Yeh JM, Botteman MF, Pashos CL, Postma M, Staginnus U. The economics of transfusion. Infusionsther Transfusions Med 2002; 29: 218-55.</p>
<p>Huse DM, Russell MW, Snydman DR, Drowns S, Hartz SC. Economic benefits of piperacillin/tazobactam for patients with suspected polymicrobial infections. J Clin Outcomes Mgmt 1998; 5: 20-30.</p>
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