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<h1>Endocrinology </h1>
<p>The ABS team has extensive experience conducting various strategic and tactical, prospective and retrospective research and consulting services in endocrinology. Examples of this work are presented here.</p>
<h2>Indications</h2>
<ul>
<li>Acromegaly</li>
<li>Cachexia</li>
<li>Cardiometabolic disorder</li>
<li>Enzyme replacement therapy</li>
<li>Fabry disease</li>
<li>Growth hormone deficiency</li>
<li>Hormone replacement therapy (HRT)</li>
<li>Lipid management</li>
<li>Lysosomal storage disease</li>
<li>Mucopolysaccharidosis (MPS) I <br />
- Hurler, Hurler-Scheie, and Scheie diseases</li>
<li>MPS II / Hunter syndrome</li>
<li>Obesity</li>
<li>Osteoporosis</li>
<li>Pancreatic insufficiency</li>
<li>Precocious puberty</li>
<li>Telemedicine</li>
</ul>
<p> </p>
<h2>Strategic Consulting and Research Examples</h2>
<ul>
<li>Global conference on economics of rare diseases</li>
<li>Health-related quality of life (HRQL) assessment strategy in growth hormone deficiency and pancreatic insufficiency</li>
<li>HRQL instrument development strategy for MPS II / Hunter syndrome</li>
<li>Publication planning in cardiometabolic risk</li>
<li>Strategic communication on the burden of Hurler / Hurler-Scheie / Scheie diseases</li>
<li>Strategic value dossier for a treatment of cachexia</li>
<li>Systematic review of cachexia</li>
</ul>
<h2>Selected Prospective Studies</h2>
<ul>
<li>Assessment of clinical, economic and HRQL burden of Fabry disease</li>
<li>HRQL instrument development and validation in MPS II / Hunter syndrome</li>
<li>HRQL instrument validation in acromegaly</li>
<li>Natural history study in lysosomal storage disease</li>
<li>Phase I study of a growth hormone for short stature in children</li>
<li>Phase III studies of HRT for secondary amenorrhea and a growth hormone antagonist for precocious puberty</li>
<li>Phase IIIb study of growth hormone for acromegaly</li>
<li>Phase IV study of HRT for menopause</li>
<li>Registry programs in growth hormone (pediatric), obesity, and osteoporosis</li>
</ul>
<h2>Selected Retrospective Studies</h2>
<ul>
<li>Analysis of cachexia using managed care data</li>
<li>Analyses of cardiometabolic diseases (hypertension, hyperlipidemia, obesity, etc.) (NHANES, Framingham Heart and Offspring Studies, ARIC)</li>
<li>Analysis of linked Medicare claims and other data to evaluate a case management system</li>
<li>Analysis of NHANES III to determine the risk of osteoporosis by patient characteristics</li>
<li>Analysis of osteoporosis in Medicaid population</li>
<li>Analysis of outcomes and costs of patients treated with growth hormone</li>
<li>Claims analysis of outcomes and costs of patients treated with growth hormone</li>
<li>GPRD analysis of myocardial infarction and stroke</li>
<li>Temporal analysis of treatment and outcomes of commercially insured individuals with precocious puberty</li>
</ul>
<h2>Selected Modeling Studies</h2>
<ul>
<li>Cost-effectiveness of HRT for the management of menopausal symptoms</li>
<li>Cost-effectiveness of HRT, raloxifene and alendronate for osteoporotic fractures within a Medicaid population</li>
<li>Economic model of cachexia</li>
<li>Economic value of measuring LDL particle concentration / particle size</li>
<li>Impact model of obesity</li>
<li>Markov model of the clinical and economic impact of various agents in the prevention and treatment of osteoporosis in the U.S. and U.K.</li>
</ul>
<h2>Selected Publications & Presentations of ABS Team Members</h2>
<p>Shulman LP, Portman DJ, Lee WC, Balu S, Joshi AV, Cobden D, Wang Q, Pashos CL. A retrospective managed care claims data analysis of medication adherence to vaginal estrogen therapy: Implications for clinical practice. J Women’s Health 2008; 17(4): 569-78. </p>
<p>Joshi AV, Munro V, Russell MW. Cost-utility of somatropin (rDNA origin) in the treatment of growth hormone deficiency in children. Curr Med Res Opin 2006; 22(2): 351-57.</p>
<p>Botteman MF, Shah NP, Lian J, Pashos CL, et al. A cost-effectiveness evaluation of two continuous-combined hormone therapies for the management of moderate-to-severe vasomotor symptoms. Menopause 2004; 11(3): 343-55.</p>
<p>Cangialose C, Yeh Y. The economics of phosphate binders in renal dialysis: a two-stage strategy for managing hyperphosphatemia. Value Health 2003; 6(3): 289.</p>
<p>Botteman MF, Wang Q, Stephens JM, Gao X, Lian J. Feasibility of simplifying complex decision trees via linear regression analysis: An application to cost effectiveness analysis of hormone therapy for menopausal symptoms. Value Health 2003; 6(3): 377.</p>
<p>Botteman MF, Shah N, Brandman J, Pashos CL. A cost-effectiveness evaluation of two continuous combined hormone replacement therapies for the management of menopausal symptoms and prevention of osteoporosis. North American Menopause Society, 13th Annual Meeting, Chicago, IL, October 4-5, 2002.</p>
<p>Gold KF, Pastores GM, Botteman MF, Yeh JM, Sweeney S, Aliski W, Pashos CL. Quality of life of patients with Fabry disease. Qual Life Res 2002; 11(4): 317-27.</p>
<p>Lenderking WR, Zacker C, Katznelson L, Vance ML, Hossain S, Tafesse E, Guacaneme AO, Pashos CL. The reliability and validity of the impact on lifestyle questionnaire in patients with acromegaly. Value Health 2000; 3(4): 261-69.</p>
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