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<h1>Diabetes </h1>
<p>The ABS team has extensive experience conducting various strategic and tactical, prospective and retrospective research and consulting services in diabetes. Examples of this work are presented here.</p>
<h2>Strategic Consulting and Research Examples</h2>
<ul>
<li> Design of diabetes clinical prediction software, outcomes tracking database, and users manual</li>
<li>Focus groups and expert panels for various projects for an oral diabetes agent</li>
<li>Instrument development in diabetes</li>
<li>Market research on the value of a glucose self-test monitoring device</li>
<li>Program conceptualization and content development for Type 2 diabetes patient education</li>
<li>Strategic assessment of a glucose monitoring and compliance promotion device</li>
<li>Strategic HRQL research for insulin delivery systems</li>
<li>Strategic outcomes assistance for diabetes disease management group on its guidelines and treatment patterns</li>
<li>Strategic planning for a diabetes agent</li>
<li>Systematic reviews of characteristics of diabetes sub-populations, compliance with treatment and diet/exercise programs in diabetes and obesity</li>
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<h2>Selected Prospective Studies</h2>
<ul>
<li> Analysis of patient satisfaction with long acting insulin</li>
<li>Development of self-administered instrument to assess patient and physician diabetes treatment choices</li>
<li>Evaluation of patient-reported outcomes (PROs) in a clinical trial in diabetes</li>
<li>Phase I studies of a monoclonal antibody for Type 1 diabetes and IGFs in Type 1 and 2 diabetes</li>
<li>Phase II study of a wound healing agent in Type 2 diabetes</li>
<li>Phase III multinational clinical trial design of HRQL and economic parameters for an oral diabetes agent</li>
<li>Phase III study of a hypoglycemic for Type 2 diabetes</li>
<li>Registry program in diabetic foot ulcers</li>
</ul>
<h2>Selected Retrospective Studies</h2>
<ul>
<li> Analyses of cardiometabolic diseases (NHANES, Framingham Heart and Offspring Studies, ARIC)</li>
<li>Analysis of Type 2 diabetes using managed care data</li>
<li>Analysis of costs of treating diabetes in home health and long-term care</li>
<li>Analysis of impact of ADA treatment guidelines for Type 2 diabetes on resource utilization and costs</li>
<li>Analysis of pharmacy claims data to assess use and persistence with oral diabetes agents</li>
<li>Examination of use of opioid medications in diabetic neuropathic pain among commercially insured individuals</li>
<li>Managed care analysis in Type 2 diabetes</li>
<li>Managed care and Medicare analysis in diabetic neuropathic pain</li>
<li>Medicaid database analysis of racial differences in resource use and costs in patients on oral diabetes agents</li>
<li>Medical chart review analysis of differences in early diabetes costs in Germany, France, and the U.K.</li>
<li>Medicare analysis of Type 2 diabetes</li>
</ul>
<h2>Selected Modeling Studies</h2>
<ul>
<li>Budget impact models of oral anti-diabetic drugs in managed care organizations</li>
<li>Design and dissemination of an interactive Type 2 diabetes model in the U.S., U.K., France, and Germany</li>
<li>Development and publication of a Type 2 diabetes short-term economic model for oral agents in the U.S.</li>
</ul>
<h2>Selected Publications & Presentations of ABS Team Members</h2>
<p>Balu S, Lee WC, Cobden D, Joshi AV, Pashos CL. Impact of drug copayment: Adherence and subsequent clinical and economic outcomes among privately-insured Type 2 Diabetes patients converting to insulin pen therapy. Manag Care Interface 2008: in press.</p>
<p>Pfützner A, Asakura T, Sommavilla B, Lee WC. Insulin delivery with FlexPen: dose accuracy, patient preferences and adherence. Expert Opin Drug Deliv 2008; in press.</p>
<p>Lee WC, Balu S, Cobden D, Joshi AV, Pashos CL. Copayment level and medication adherence in Type 2 diabetes patients managed with insulin aspart pen therapy. Value Health 2007; in press.</p>
<p>Balu S, Lee WC, Cobden D, Joshi AV, Pashos CL. Impact of initiating or converting to treatment with an insulin aspart analog pen on medication adherence in Type 2 diabetes patients on vial/syringe insulin. Value Health 2007; in press.</p>
<p>Cobden D, Lee WC, Balu S, Joshi AV, Pashos CL. Health outcome and economic impact of therapy conversion to a biphasic insulin analogue pen among privately insured patients with type 2 diabetes mellitus. Pharmacotherapy 2007; 27(7): 948-52.</p>
<p>Lee WC, Balu S, Cobden D, Joshi, AV, Pashos CL. Insulin Administration among type 2 diabetes patients: health outcomes and economic impact of conversion to a biphasic analogue insulin pen. ADA, 67th Annual Scientific Sessions, Chicago, IL, June 22- 27, 2007.</p>
<p> Balu S. Incremental treatment expenditure of diabetes in the United States. Manag Care Interface 2007; 20(4): 20-27.</p>
<p>Lee WC, Balu S, Cobden D, Joshi AV, Pashos CL. Medication adherence and associated health economic impact in type 2 diabetes patients converting to insulin pen therapy: A third party managed care claims data analysis. Clin Ther 2006; 28(10): 1712-25.</p>
<p>Lee WC, Balu S, Cobden D, Joshi AV, Pashos CL. Prevalence and economic consequences of medication adherence in diabetes: A systematic literature review. Manag Care Interface 2006; 19(7): 31-41.</p>
<p>Lee WC. Understanding Patient Adherence and its Economic Consequences. ISPOR Connections, Vol. 12 No 3: June 15, 2006.</p>
<p>Lee WC, Nicklasson L, Cobden D, Chen E, Conway D, Pashos CL. Short-term economic impact associated with occupational needlestick injuries among acute care nurses. Curr Med Res Opin 2005; 21(12): 1915-22.</p>
<p>Cobden D, Pashos CL, et al. Needlestick injuries in the care of patients with diabetes. Life Sciences Bus & Tech Rev 2005; 5: 74-76.</p>
<p>Lee JM, Botteman MF, Nicklasson L, Cobden D, Pashos CL. Needlestick injury in acute care nurses caring for patients with diabetes mellitus: a retrospective study. Curr Med Res Opin 2005; 21(5): 741-47.</p>
<p>Lee WC, Hoffman MS, Johnsrud M, Pashos CL. Insulin augmentation in a Texas Medicaid population with Type 2 diabetes. Drug Benefit Trends 2005; 17: 118-22.</p>
<p>Lee JM, et al. Needlestick injuries in the United States: Epidemiologic, economic, and quality of life issues. AAOHN J 2005; 53(3): 117-33.</p>
<p>Ramsdell JW, et al. Economic model of first-line drug strategies to achieve recommended glycaemic control in newly diagnosed Type 2 diabetes mellitus. Pharmacoeconomics 2003; 21(11): 819-37.</p>
<p>Botteman MF, Gao X, et al. Using linear regression to approximate results of decision analysis: an application to a cost comparison across 3 first-line drug strategies in Type 2 diabetes. Value Health 2003; 6(3): 331-32.</p>
<p>Stephens JM, Blak BT, Gold KF, Botteman MF, Pashos CL, et al. Persistence patterns with oral hypoglycemic agents in Type 2 diabetes. J Clin Outcomes Manag 2002; 9(9): 491-499.</p>
<p>Menzin J, Langley-Hawthorne C, Friedman M, Boulanger L, Cavanaugh R. The potential short-term economic benefits of improved glycemic control: a managed-care perspective. Diabetes Care 2001; 24(1): 51-55.</p>
<p>Pashos CL, et al. Costs of treating naïve patients with Type 2 diabetes - a comparison between the United Kingdom and France. ISPOR, 2nd Annual European Conference, Edinburgh, Scotland, November 11-13, 1999.</p>
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