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<h1>Cardiovascular Diseases </h1>
<p>The ABS team has extensive experience conducting various strategic and tactical, prospective and retrospective research and consulting services in cardiovascular diseases. Examples of this work are presented here.</p>
<h2>Indications</h2>
<ul>
<li>Acute coronary syndrome (ACS)</li>
<li>Acute myocardial infarction (AMI)</li>
<li>Angina</li>
<li>Aortic stenosis</li>
<li>Arrhythmia</li>
<li>Atrial fibrillation (AF)</li>
<li>Cardiometabolic risk</li>
<li>Congestive heart failure (CHF)</li>
<li>Coronary revascularization procedures</li>
<li>Critical limb ischemia</li>
<li>Dyslipidemia</li>
<li>Hypertension (HTN)</li>
<li>Imaging and screening</li>
<li>Minimally-invasive heart procedures</li>
<li>Mitral valve regurgitation</li>
<li>Peri-operative myocardial ischemia</li>
<li>Stroke: ischemic and hemorrhagic</li>
<li>Venous thromboembolism</li>
</ul>
<h2>Strategic Consulting and Research Examples</h2>
<ul>
<li>Economic justification for formulary inclusion in Canadian provinces </li>
<li>Multiple AMCP-compliant dossiers for an ACE-inhibitor in CHF and HTN and in echocardiography </li>
<li>Outcomes research and reimbursement plans in AF, ACS, CHF, and diagnostics </li>
<li>Strategic economic research plan for minimally-invasive heart surgery </li>
<li>Strategic publication planning in cardiometabolic disorder </li>
<li>Strategic research on provider and payer perceptions of HTN </li>
<li>Systematic review of effect of beta blockers on HRQL in CHF, and in mitral valve regurgitation, and aortic stenosis</li>
</ul>
<h2>Selected Prospective Studies</h2>
<ul>
<li>Economic and HRQL aspects of European clinical trial in AF</li>
<li>Economic evaluation of HTN in Medicaid</li>
<li>Multiple economic and HRQL piggyback studies in ACS, CHF</li>
<li>Patient preference study of warfarin vs. aspirin vs. no treatment in AF</li>
<li>Phase III and IV studies in HTN of ACE inhibitors, a beta blocker, a calcium channel blocker, and a diuretic</li>
<li>Registries in percutaneous coronary intervention, coronary revascularization procedures, and cardiac imaging and outcomes</li>
</ul>
<h2>Selected Retrospective Studies</h2>
<ul>
<li>Analyses of cardiometabolic risk (NHANES, Framingham, ARIC)</li>
<li>Analysis of impact of HTN-related therapeutic inertia</li>
<li>Chart review-based analysis of care management and treatment in HTN</li>
<li>Hospital database analysis of trends in the use of drug therapies in AMI</li>
<li>Managed care analysis of clinical and economic impact in dyslipidemia</li>
<li>Medicare analyses of care and costs of AMI, AF, cardiac pacemakers, hemorrhagic and ischemic stroke</li>
<li>Medical record-based analysis of stroke</li>
<li>Multiple employer studies in HTN</li>
<li>Prevalence and care in critical limb ischemia using HCUP</li>
</ul>
<h2>Selected Modeling Studies</h2>
<ul>
<li>Assessment of an economic model for thrombin receptor agonist therapy in ACS</li>
<li>Budget impact model of HTN in managed care organizations</li>
<li>Cost-effectiveness model of prevention of complications of deep vein thrombosis</li>
<li>Cost-effectiveness model in pulmonary HTN in an Asian market</li>
<li>Economic analyses of pharmacologic stress imaging agents, AF, angina, and transmyocardial revascularization</li>
<li>Economic model in CHD</li>
<li>Multiple methods for calculating personal risk in cardiovascular disease</li>
</ul>
<h2>Selected Publications & Presentations of ABS Team Members</h2>
<p>Lee WC, Lamas GA, Balu S, Spalding S, Wang Q, Pashos CL. Direct treatment cost of atrial fibrillation in the elderly American population: A Medicare perspective. J Med Econ 2008; in press.</p>
<p>Christensen MC, Previgliano I, Caparelli FJ, Lerman D, Lee WC, Wainsztein NA. Acute treatment costs of intracerebral hemorrhage and ischemic stroke in Argentina. Acta Neurol Scand 2008; in press.</p>
<p>Wilson PWF, Bozeman SR, Burton TM, Hoaglin DC, Ben-Joseph R, Pashos CL. Prediction of first events of coronary heart disease and stroke with consideration of adiposity. Circulation 2008; 118(2): 124-30.</p>
<p>Harshman RS, Richerson GT, Hadker N, Greene BL, Brown TM, Foster TS, et al. Impact of a hypertension management/health promotion program on commercial driver’s license employees of a self-insured utility company. J Occup Environ Med 2008; 50(3): 359-65.</p>
<p>Lee WC, Joshi AV, Wang Q, Pashos CL, et al. Mortality and morbidity among elderly Americans with different stroke sub-types. Adv Ther 2007; 24(2): 258-68.</p>
<p>Denevich S, Boci K, Reddy P. Cost–effectiveness of amiodarone in cardiac surgery. Expert Rev Pharmacoecon Outcomes Res 2007; (1): 19-30.</p>
<p>Scranton RE, Bozeman SR, Burton TM, Hoaglin DC, et al. Simple demographic model to predict multiple cardiometabolic risk factors in two well-known observational cohorts. Value Health 2007; 10(suppl. 1): S37-44.</p>
<p>Russell MW, Joshi AV, Boulanger L, et al. Predictors of hospital length of stay and cost in patients with ICH. Neurology 2006; 67(7): 1279-81.</p>
<p>Boulanger L, Hauch O, Friedman M, Foster T, et al. Warfarin exposure and the risk of thromboembolic and major bleeding events among Medicaid patients with atrial fibrillation. Ann Pharmacother 2006; 40(6): 1024-29.</p>
<p>Boulanger L, Kim J, Friedman M, Hauch O, Foster T, et al. Patterns of use of antithrombotic therapy and quality of anticoagulation among patients with non-valvular atrial fibrillation in clinical practice. Int J Clin Pract 2006; 60(3): 258-64.</p>
<p>Mackey WC, Fleisher LA, Haider S, Sheikh S, Cappelleri JC, Lee WC, Wang Q, et al. Perioperative myocardial ischemic injury in high risk vascular surgery patients: Incidence and clinical significance in a prospective clinical trial. J Vasc Surg 2006; 43(3): 533-38.</p>
<p>Lee WC, Christensen MC, Joshi AV, Pashos CL. Long-term cost of stroke subtypes among Medicare beneficiaries. Cerebrovasc Dis 2007; 23(1): 57-65.</p>
<p>Lee WC, Chavez Y, et al. Economic burden of heart failure: A summary of recent literature. Heart Lung 2004; 33(6): 362-71.</p>
<p>Caprini J, Botteman MF, Stephens JM, et al. Economic burden of long-term complications of deep vein thrombosis after total hip replacement surgery in the United States. Value Health 2003; 6(1): 59-74.</p>
<p>Singh G, Miller JD, Huse DM, Pettitt D, D’Agostino RB, Russell MW. The consequences of increased systolic blood pressure in patients with osteoarthritis and rheumatoid arthritis. J Rheumatol 2003; 30(4): 714-19.</p>
<p>Russell MW, et al. Use of managed care claims data in the risk assessment of venous thromboembolism in outpatients. Am J Manag Care 2002; 8(1 Suppl): S3-S9.</p>
<p>Huse DM, Cummins G, Taylor DC, Russell MW. Outpatient treatment of venous thromboembolism with low molecular weight heparin: an economic evaluation. Am J Manag Care 2002; 8(1 Suppl): S10-S16.</p>
<p>Singh G, Miller JD, Lee FH, Pettitt D, Russell MW. Prevalence of cardiovascular disease risk factors among U.S. adults with self-reported osteoarthritis: Data from NHANES III. Am J Manag Care 2002; 8(15 Suppl): S383-S391.</p>
<p>Russell MW, Huse DM, Miller JD, et al. Cost-effectiveness of HMG-CoA reductase inhibition in Canada. Can J Clin Pharmacol 2001; 8(1): 9-16.</p>
<p>Krotenberg R, Adler U, Pomeranz B, Miller JD, Russell MW. Dalteparin vs. enoxaparin as prophylaxis for deep-vein thrombosis after total hip or knee arthroplasty: a retrospective analysis. Am J Phys Med Rehabil 2001; 80(12): 889-95.</p>
<p>D’Agostino RB, Russell MW, et al. Primary and subsequent coronary risk appraisal: new results from The Framingham Study. Am Heart J 2000; 139: 272-81.</p>
<p>Tu JV, Naylor CD, Pashos CL, et al. Coronary angiography and revascularization after AMI: Which rate is right? Eur Heart J 1998; 19(4): 529-30.</p>
<p>Miller JD, Huse DM, Russell MW, et al. Economic segmentation of statins: price versus efficiency. J Am Coll Cardiol 1998; 30(Suppl. 2).</p>
<p>Russell MW, et al. Direct medical costs of coronary artery disease in the United States. Am J Cardiol 1998; 81(9): 1110-15.</p>
<p>Huse DM, Russell MW, Miller JD, et al. Cost-effectiveness of statins. Am J Cardiol 1998; 82(11): 1357-63.</p>
<p>Tu JV, Pashos CL, et al. Use of cardiac procedures and outcomes in elderly patients with myocardial infarction in the United States and Canada. NEJM 1997; 336(21): 1500-05.</p>
<p>Guadagnoli E, Hauptman PJ, Ayanian JZ, Pashos CL, et al. Variation in the use of cardiac procedures after acute myocardial infarction. NEJM 1995; 333(9): 573-78.</p>
<p>Lamas GA, Pashos CL, et al. Permanent pacemaker selection and subsequent survival in elderly Medicare pacemaker recipients. Circulation 1995; 91(4): 1063-69.</p>
<p>Ayanian JZ, Hauptman P, Guadagnoli E, Antman EM, Pashos CL, et al. Knowledge and practices of generalist and specialist physicians regarding drug therapy for acute myocardial infarction. NEJM 1994; 331(17): 1136-42.</p>
<p>Pashos CL, et al. Trends in the use of drug therapies in patients with acute myocardial infarction: 1988-92. J Am Coll Cardiol 1994; 23(5): 1023-30.</p>
<p>Pashos CL, et al. Temporal changes in the care and outcomes of elderly patients with acute myocardial infarction, 1987 through 1990. JAMA 1993; 270(15): 1832-36.</p>
<p> </p>
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