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<h1>Allergy & Respiratory Diseases </h1>
<p>The ABS team has extensive experience conducting various strategic and tactical, prospective and retrospective research and consulting services in allergy and respiratory diseases. Examples of this work are presented here.</p>
<h2>Indications</h2>
<ul>
<li>Allergic rhinitis</li>
<li>Asthma</li>
<li>Chronic obstructive pulmonary disease (COPD)</li>
<li>Chronic sinusitis</li>
<li>Emphysema</li>
<li>Infections in cystic fibrosis</li>
<li>Influenza</li>
<li>Lung cancer</li>
<li>Pertussis (whooping cough)</li>
<li>Respiratory syncytial virus (RSV)</li>
<li>Rhinoconjunctivitis</li>
<li>Smoking-related diseases</li>
<li>Strep. pneumoniae</li>
<li>Tuberculosis</li>
</ul>
<h2>Strategic Consulting and Research Examples</h2>
<ul>
<li>Creation of patient materials in multiple languages promoting effective asthma treatment</li>
<li>Development of slide kit and model (CD-ROM) to demonstrate the high burden of allergic rhinitis to managed care organizations (MCOs)</li>
<li>Strategic economic environment assessment for chronic sinusitis</li>
<li>Strategic global market assessment of tuberculosis vaccine</li>
<li>Strategic positioning and early economic assessment of adult RSV vaccine in Europe and the U.S.</li>
<li>Strategic pricing and reimbursement intelligence research for pediatric vaccine against Strep. pneumoniae</li>
</ul>
<h2>Selected Prospective Studies</h2>
<ul>
<li>Design and implementation of a patient registry for an airway clearance device in the U.S.</li>
<li>Design and implementation of educational strategies and interventions for controlling asthma in the inner city</li>
<li>Development and testing of an asthma and rhinoconjunctivitis symptom scale</li>
<li>Development and validation of a rhinitis questionnaire to help physicians track treatment outcomes</li>
<li>Economic substudy of a clinical trial for a pediatric Strep. pneumoniae vaccine</li>
<li>Economic substudy of a clinical trial of inhaled influenza vaccine</li>
<li>Physician survey of trends in the management of allergic rhinitis</li>
</ul>
<h2>Selected Retrospective Studies</h2>
<ul>
<li>Analysis of the cost of smoking using multiple national databases</li>
<li>Assessment of asthma management among Medicaid beneficiaries</li>
<li>Burden of illness study for COPD using HCUP and NAMCES</li>
<li>Drug utilization review in Medicaid to assess baseline adherence to national asthma treatment guidelines</li>
</ul>
<h2>Selected Modeling Studies</h2>
<ul>
<li>Budget impact model of asthma management for MCOs</li>
<li>Cost-effectiveness model of RSV vaccine</li>
<li>Cost of infections in cystic fibrosis</li>
<li>Economic impact model of allergic rhinitis from a managed care perspective</li>
<li>Economic model of vaccine for the prevention of Strep. pneumoniae in adults</li>
<li>Multiple economic models of vaccine for the prevention of pertussis in adults and specific patient populations</li>
</ul>
<h2>Selected Policy Engagements</h2>
<ul>
<li>Analysis of smoking-attributable lung cancer</li>
<li>Contributions to Surgeon General report on smoking</li>
<li>Input into smoking policies of several U.S. states</li>
</ul>
<h2>Selected Publications & Presentations of ABS Team Members</h2>
<p>Marton J, Boulanger L, et al. Assessing the costs of chronic obstructive pulmonary disease: the state Medicaid perspective. Respir Med 2006; 100(6): 996-1005.</p>
<p>Boulanger L, Khandker RK, Russell MW. Resource use and cost of healthcare services among patients newly diagnosed with idiopathic pulmonary fibrosis: evidence from a large state Medicaid program. Value Health 2006; 9(3): A93-A94.</p>
<p>Foster TS, Miller JD, Marton JP, Caloyeras JP, Russell MW, Menzin J. Assessment of the economic burden of COPD in the U.S.: A review and synthesis of the literature. COPD 2006; 3(4): 211-8.</p>
<p>Miller JD, Foster T, Boulanger L, Chace M, Russell MW, et al. Direct costs of COPD in the U.S.: An analysis of Medical Expenditure Panel Survey (MEPS ) data. COPD 2005; 2(3): 311-18.</p>
<p>Purdy KW, Hay JW, Botteman MF, Ward JI. Evaluation of strategies for use of a cellular pertussis vaccine in adolescents and adults: A cost-benefit analysis. Clin Infect Dis 2004; 39: 20-8.</p>
<p>Schoenwetter WF, Dupclay L, Appajosyula S, Botteman MF, Pashos CL. Economic impact and quality of life burden of allergic rhinitis. Curr Med Res Opin 2004; 20(3): 305-17.</p>
<p>Diette G, Cangialose C, Knight T, et al. Long-term benefits of antibiotic treatment in reducing recurrence rates and resource utilization in acute exacerbations of chronic bronchitis (AECB). European Respiratory Society, 13th Annual Congress, Vienna, Austria, September 27 - October 1, 2003.</p>
<p>Kornfield T, Botteman MF, Pashos CL. Cost-effectiveness of vaccinating adult close contacts with Boostrix®. International Society for Pharmacoeconomics and Outcomes Research (ISPOR), 7th Annual Meeting, Arlington, VA, May 19-22, 2002.</p>
<p>Huse DM, Russell MW, et al. Anti-inflammatory therapy reduces total costs of asthma care compared to bronchodilation: the Asthma Outcomes Registry. Am J Manag Care 2000; 6: 1045-50.</p>
<p>Botteman MF, Staginnus U, Pashos CL. Preliminary assessment of the economic value of adult pertussis booster vaccination: vaccinating hospital staff. ISPOR, 5th Annual Meeting, Arlington, VA, May 21-24, 2000.</p>
<p>Russell MW, Huse DM, Miller JD, Hartz SC. Estimating healthcare costs in the absence of financial data: a case study. Value Health 1999; 2:222.</p>
<p>Huse DM, Hartz SC, Russell MW, Piercy GE, Weiss ST. Allergic rhinitis may worsen asthma symptoms in children: The Asthma Outcomes Registry. Eur Resp J 1998; 12(Suppl 29): 50s.</p>
<p>Russell MW, Huse DM, Taylor DCA, Weiss ST, Hartz SC. Asthma treatment costs are higher in patients with low compliance with inhaled steroids. Am J Resp Crit Care Med 1998; 157: A221.</p>
<p>Huse DM, Russell MW, Kuriyama N, Weiss ST, Hartz SC. Asthma treatment costs are increased in patients with sinusitis. Am J Resp Crit Care Med 1998; 157: A617.</p>
<p>Huse DM, Russell MW, Miller JD, Weiss ST, Hartz SC. Asthma treatment costs are increased in children with allergic rhinitis. Am J Resp Crit Care Med 1998; 157: A617.</p>
<p>Russell MW, Huse DM, Taylor DCA, Weiss ST, Hartz SC . Asthma treatment costs are increased in adults with allergic rhinitis. Am J Resp Crit Care Med 1998; 157: A617.</p>
<p>Berger R, Pashos C. Use of lung volume reduction surgery. American Association for Thoracic Surgery, Annual Meeting, Boston, MA, May 3, 1998.</p>
<p>Rigotti NA, Pashos CL. No-smoking laws in the United States: an analysis of state and city actions to limit smoking in public places and workplaces. JAMA 1991; 266(22): 3162-67.</p>
<p>Stoto MA, Pashos CL, Schuster M, Rigotti NA. Pregnancy as a target of opportunity for smoking intervention. In: Smoking and Health 1987, Proceedings of the 6th World Conference on Smoking and Health. Aoki M, Hisamichi S, Tominaga S, eds. Elsevier Science Publishers, Amsterdam, 509-11, 1988.</p>
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